Results 71 to 80 of about 381,169 (287)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Recurrent Gastrointestinal Bleeding in a Man with Osler-Weber-Rendu Syndrome and Intestinal Varices

Canadian Journal of Gastroenterology, 1988
A patient with Osler-Weber-Rendu disease and idiopathic intestinal varices who presented with recurrent gastrointestinal hemorrhage and iron deficiency anemia is reported. The unique coexistence of these two rare disorders is discussed and the literature
Robert N. Clark, William G. Paterson, Laurington R. DaCosta, Ivan T. Beck   +3 more
doaj   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

The influence of in vitro gastrointestinal digestion on the chemical composition and antioxidant and enzyme inhibitory capacities of carob liqueurs obtained with different elaboration techniques [PDF]

, 2019
Carob liqueur is a traditional Mediterranean alcoholic beverage obtained via a wide range of production techniques contributing to the different organoleptic attributes of the final product.
Coelho, Natacha, Gonçalves, Sandra, Pérez-Santín, Efrén, Rodríguez Solana, Raquel, Romano, Anabela, Santos-Rufo, Antonio   +5 more
core   +1 more source

Cellular and clinicopathological features of the IL-33/ST2 axis in human esophageal squamous cell carcinomas

Cancer Cell International, 2018
Background Emerging evidence has suggested that interleukin (IL)-33 and its primary functional receptor ST2 are involved in the pathogenesis of tumorigenesis.
Guanglin Cui, Jingli Ren, Gang Xu, Zhenfeng Li, Wei Zheng, Aping Yuan   +5 more
doaj   +1 more source

Rectal bleeding as a symptom of solitary rectal ulcer syndrome mimicking rectal neoplasm on colonoscopy: A case report

Clinical Case Reports, 2023
Key Clinical Message Patients complaining of rectal bleeding, constipation, and a suspicious mass in colonoscopy should undergo biopsy. Histological features such as fibromuscular obliteration in the lamina propria favor SRUS, a benign disorder.
Masood Faghih Dinevari, Amirtaher Eftekharsadat, Mahdi Tarverdizadeh, Seyyed Mahdi Rasulimanesh, Ali Riazi, Amirreza Jabbaripour Sarmadian, Samaneh Abbasian   +6 more
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

An evaluation of 605 endoscopic examination in a rural setting, Lacor Hospital in Northern Uganda [PDF]

, 2016
Introduction: The aim of this study was to evaluate the profile of esophagogastroduodenal (EGDS) diseases diagnosed by upper endoscopy in a rural area of Uganda in a retro-protective study of 605 patients.
Alema NO, Ogwang DM, Okello TR, Pecorella I.   +3 more
core   +1 more source

Lactoferrin in Gastrointestinal Disease

Internal Medicine, 2009
Lactoferrin, a major whey protein, is a red iron-binding protein present mainly in external secretions such as breast milk and in polymorphonuclear neutrophils. The presence of lactoferrin in body fluids is proportional to the flux of neutrophils and its assessment can provide a reliable biomarker for inflammation.
Hiroshi Ishiguro, Tetsuo Hayakawa, Chun Xiang Jin, Shigeru B. H. Ko, Motoji Kitagawa   +4 more
openaire   +4 more sources