Results 201 to 210 of about 578,043 (298)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia   +4 more
wiley   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad   +5 more
wiley   +1 more source

Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme—CaPP

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley   +1 more source

Upper gastrointestinal hemorrhage as a manifestation of systemic lupus erythematosus: a case report. [PDF]

open access: yesJ Med Case Rep
Tukeni KN   +6 more
europepmc   +1 more source

Human Protein Biomarkers Outperform Bacterial Proteins in Colorectal Cancer Detection

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) generally develops from precancerous adenomatous lesions, including advanced adenomas (AA), through a sequence of carcinogenic molecular alterations. The composition of the gut microbiota and the fecal proteome is known to differ between individuals with AA and CRC compared to controls, providing opportunities for ...
Roza C. M. Opperman   +12 more
wiley   +1 more source

Decline of the Sengstaken-Blakemore tube: A review of shifting practices in gastrointestinal hemorrhage management. [PDF]

open access: yesWorld J Crit Care Med
Kogilathota Jagirdhar GS   +6 more
europepmc   +1 more source

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