Results 61 to 70 of about 721,268 (287)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Management of bacterial infection in the liver transplant candidate [PDF]

, 2018
Bacterial infection (BI) is a common cause of impairment of liver function in patients with cirrhosis, especially in the liver transplant candidates. These patients share an immunocompromised state and increased susceptibility to develop community and ...
Becchetti, Chiara, Burra, Patrizia, Ferrarese, Alberto, Gambato, Martina, Germani, Giacomo, Russo, Francesco Paolo, Sciarrone, SALVATORE STEFANO, Senzolo, Marco, Shalaby, Sarah, Zanetto, Alberto   +9 more
core   +1 more source

Validation of the Safe Application of Tokyo Guideline 2018 (TG18) Severity Grading and Treatment Algorithm in Super‐Elderly Patients Aged 85 and Over With Acute Cholecystitis: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background With population aging and extended healthy life expectancy, the management of acute cholecystitis (AC) in patients aged ≥ 85 years has evolved. However, the Tokyo Guidelines 2018 (TG18) for AC provide no specific risk assessment criteria for this population.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shinogu Hatano, Shojiro Hata, Hirokazu Yamaguchi   +9 more
wiley   +1 more source

Cholangitis in three critically ill patients after a severe CoVID-19 infection

IDCases, 2021
Coronavirus disease 2019 (CoVID-19) is a viral disease. Although the predominant presentation is respiratory disease, other manifestations such as gastrointestinal manifestations are commonly reported.
Cyrille Gourjault, Hassan Tarhini, Mayda Rahi, Michael Thy, Diane Le Pluart, Christophe Rioux, Marion Parisey, Sophie Ismael, Ali al rida Aidibi, Valerie Paradis, Jade Ghosn, Yazdan Yazdanpanah, François-Xavier Lescure, Anne Gervais   +13 more
doaj   +1 more source

Gastrointestinal Symptoms Associated With Unfavorable Prognosis of COVID-19 Patients: A Retrospective Study

Frontiers in Medicine, 2020
Background and Aim: The global pandemic of COVID-19 has posed an enormous threat to the economy and people's lives across various countries. Patients with COVID-19 most commonly present with respiratory symptoms.
Rong Chen, Yanping Yu, Wei Li, Ya Liu, Jing Lu, Fangyue Chen, Qin Zhou, Z. Xia, Ling Gao, Qingtao Meng, D. Ma   +10 more
semanticscholar   +1 more source

Extralevator Abdominoperineal Excision Improves Overall Survival Compared to Standard Abdominoperineal Excision: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis of 38 studies, encompassing over 5000 patients, compared extralevator abdominoperineal excision (ELAPE) with standard abdominoperineal excision (APE) in patients with advanced low rectal cancer. ELAPE was associated with significantly improved overall and disease‐free survival, reduced intraoperative perforation
Sarolta Beáta Kávási, Diana‐Elena Floria, Anett Rancz, Dániel Sándor Veres, Nándor Faluhelyi, Pál Miheller, Péter Hegyi, Szabolcs Ábrahám   +7 more
wiley   +1 more source

Pediatric Gastrointestinal Endoscopy: European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) and European Society of Gastrointestinal Endoscopy (ESGE) Guidelines [PDF]

, 2017
: This Guideline refers to infants, children and adolescents aged 0–18 years. The areas covered include: indications for diagnostic and therapeutic esophagogastroduodenoscopy and ileo-colonoscopy; endoscopy for foreign body ingestion; corrosive ingestion
Aabakken, L. (Lars), Amil-Dias, J. (Jorge), Benninga, M.A. (Marc), Brownstone, E. (Eva), Dall’Oglio, L. (Luigi), Dolak, W. (Werner), Dumonceau, J.M., Everett, S. (Simon), Furlano, R. (Raoul), Gerner, P. (Patrick), Hassan, C. (Cesare), Hlava, Š. (Štěpán), Huber, W.D. (Wolf Dietrich), IJsselstijn, H. (Hanneke), Keil, R. (Radan), Landi, R. (Rosario), Orel, R. (Rok), Romano, C. (Claudio), Spaander, M.C.W. (Manon), Tabbers, M.M., Tavares, M. (Marta), Thomson, M. (Mike), Tringali, A. (A.), Tzvinikos, C. (Christos), Vandenplas, Y. (Yvan), Vecsei, A. (Andreas), Viala, J. (Jérôme), Zambelli, A. (Alessandro)   +27 more
core   +2 more sources

Clinical utility of pharyngeal high‐resolution manometry with impedance for upper esophageal sphincter dysfunction in gastroenterology

Advances in Digestive Medicine, EarlyView.
Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar, Taher Omari, Michal Szczesniak, Chien‐Lin Chen, Richard Heddle, Charles Cock   +5 more
wiley   +1 more source

Clinical Presentation of the Longest Reported Living Individual With Bent Bone Dysplasia—FGFR2‐Related

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The FGFR2 gene, encoding the FGFR2 protein, plays a crucial role in embryonic cell development, particularly in bone tissue. Bent Bone Dysplasia (BBD), FGFR2‐related (MIM# 614592), is a rare severe skeletal dysplasia characterized by craniofacial differences, reduced bone mineral density, and bowed long bones.
Cheyenne Bates, Pardeep Gill, Matthew Choi, Frances Mahon, Blake Yarascavitch, Audrey Lim, Resham Ejaz   +6 more
wiley   +1 more source

The effect of premedication with butorphanol or methadone on the ease of duodenal intubation

Veterinary Evidence
PICO Question In adult dogs undergoing upper gastrointestinal (GI) endoscopy, does premedication with butorphanol compared to premedication with methadone make duodenal intubation easier?   Clinical bottom line Category of research Treatment.
Charlotte Swanson
doaj   +1 more source