Results 141 to 150 of about 774,427 (331)

Influence of Maternal Prepregnancy Obesity and Excessive Gestational Weight Gain on Maternal and Child Gastrointestinal Microbiome Composition: A Systematic Review

Biological Research for Nursing, 2019
Background: Maternal obesity is a well-known risk factor for significant obstetric and neonatal complications. The influence of the gastrointestinal microbiome in the setting of maternal obesity during pregnancy is less understood.
C. Dreisbach, Stephanie Prescott, Jeanne L Alhusen   +2 more
semanticscholar   +1 more source

Development of the Gut Microbial Immune and Epithelial Cellular System (GutMICS) to Investigate the Immunological Role of Gut Anaerobes

Biotechnology and Bioengineering, EarlyView.
Abstract The gut microbiota plays an essential role in host health by regulating gut barrier function and immune system homeostasis. However, research into the physiological and immunological functions of the gut microbiota using In Vitro models that mimic the immune environment of the gut remains limited. Herein, we developed the Gut Microbial Immune &
Seo‐Young Kwon, Sung‐Hyun Jo, Joonha Park, Ji‐Hyeon Park, Ye‐Rim Kim, Ji‐Hyun Baek, Min‐Gyu Kim, Bo‐Gyeong Choi, Na Youn Hong, Hee Kyoung Jung, Hee‐Wook Ryu, Jessie S. Jeon, Yun‐Gon Kim   +12 more
wiley   +1 more source

The gastrointestinal microbiome: a malleable, third genome of mammals [PDF]

, 2009
Ian M. Carroll, David W. Threadgill, David W. Threadgill   +2 more
openalex   +1 more source

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

The gut microbiome: an orchestrator of xenobiotic metabolism

Acta Pharmaceutica Sinica B, 2020
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxicants,
Stephanie L. Collins, Andrew D. Patterson   +1 more
doaj  

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

The equine gastrointestinal microbiome: impacts of weight-loss

BMC Veterinary Research, 2019
Background Obesity is an important equine welfare issue. Whilst dietary restriction is the most effective weight-loss tool, individual animals range in their weight-loss propensity. Gastrointestinal-derived bacteria play a fundamental role in host-health
P. Morrison, C. J. Newbold, Eleanor Jones, H. Worgan, D. Grove-White, A. Dugdale, C. Barfoot, P. Harris, C. Argo   +8 more
semanticscholar   +1 more source

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study.

PLoS ONE
ObjectiveThe gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis.
Matthew VanOrmer, Maranda Thompson, Melissa Thoene, Jean-Jack Riethoven, Sathish Kumar Natarajan, Corrine Hanson, Ann Anderson-Berry   +6 more
doaj   +1 more source

Distinct Patterns of Dynamical Regulation in Passive Sensor Data Following Binge and Purge Behaviors

International Journal of Eating Disorders, EarlyView.
ABSTRACT Background Binge eating is a cardinal symptom of binge‐eating disorder (BED) and bulimia nervosa (BN), while recurrent purging is specific to BN (American Psychiatric Association, 2022). These behaviors are associated with health consequences (e.g., gastrointestinal, cardiovascular, and metabolic problems; Sheehan & Herman, 2015). The distress‐
Jonathan E. Butner, Laura M. Thornton, Robyn E. Kilshaw, Rachael E. Flatt, Qinxin Shi, Pascal R. Deboeck, Jenna Tregarthen, Stuart Argue, Brian R. W. Baucom, Cynthia M. Bulik   +9 more
wiley   +1 more source