Results 301 to 310 of about 155,584 (325)

A Population‐Based Matched Cohort Study of Extra‐Digestive Cancer Incidence and Mortality in Individuals With and Without Inflammatory Bowel Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
This illustration summarises our primary findings highlighting the rising incidence of certain extra‐digestive cancers among persons with IBD over the 25‐year study duration (left), and the relative rates of extra‐digestive cancer incidence and mortality among persons with IBD in recent years (2010–2019) compared to their age‐ and sex‐matched controls (
Sanjay K. Murthy, Faria Ahmed, Michael Pugliese, Monica Taljaard, Parul Tandon, Priscilla Matthews, Gilaad G. Kaplan, Stephanie Coward, Charles N. Bernstein, Eric I. Benchimol, M. Ellen Kuenzig, Laura E. Targownik, Harminder Singh, on behalf of the Canadian Gastro‐Intestinal Epidemiology Consortium (CanGIEC)   +13 more
wiley   +1 more source

Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt

Alimentary Pharmacology &Therapeutics, EarlyView.
Diabetes mellitus independently increases the risk of hepatic encephalopathy following TIPS placement in patients with cirrhosis. These findings emphasize the need for careful risk assessment in patients with cirrhosis and portal hypertension complications undergoing TIPS.
Michelle Spaan, Ellen Werner, Willemijn Dijkstra, Nicole E. Erler, Diederik Bijdevaate, Sarwa Darwish Murad, Milan J. Sonneveld, Caroline M. den Hoed, Anne van Eldere, Dave S. Sprengers, Willem‐Pieter Brouwer, Robert J. de Knegt, Harry L. A. Janssen, Kay Pieterman, Sandra Coenen, Raoel Maan, Adriaan J. van der Meer   +16 more
wiley   +1 more source

Spontaneous Bacterial Peritonitis Is Associated With High Mortality, Which Interacts With Antibiotic Prophylaxis in a National Cirrhosis Cohort

Alimentary Pharmacology &Therapeutics, EarlyView.
In a national cohort of newly decompensated Veterans with cirrhosis, SBP and recurrences are linked with higher death and need for liver transplant. SBP prophylaxis, whether primary or secondary, worsens resistance and interacts with mortality but not liver transplant.
Scott Silvey, Nilang Patel, Jacqueline G. O'Leary, Timothy Morgan, John D. Markley, Sofia S. Jakab, Heather Patton, Shari Rogal, Jasmohan S. Bajaj   +8 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

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The Microbiome in Gastrointestinal Cancers

Gastroenterology Clinics of North America, 2022
The human microbiome has been recognized as increasingly important to health and disease. This is especially prescient in the development of various cancers, their progression, and the microbiome's modulation of various anticancer therapeutics. Mechanisms behind these interactions have been increasingly well described through modulation of the host ...
Michael G, White, Jennifer A, Wargo
openaire   +2 more sources

The chicken gastrointestinal microbiome

FEMS Microbiology Letters, 2014
The domestic chicken is a common model organism for human biological research and of course also forms the basis of a global protein industry. Recent methodological advances have spurred the recognition of microbiomes as complex communities with important influences on the health and disease status of the host.
Brian B, Oakley, Hyun S, Lillehoj, Michael H, Kogut, Woo K, Kim, John J, Maurer, Adriana, Pedroso, Margie D, Lee, Stephen R, Collett, Timothy J, Johnson, Nelson A, Cox   +9 more
openaire   +2 more sources

The Gastrointestinal Microbiome in Infant Colic

MCN: The American Journal of Maternal/Child Nursing, 2022
Abstract The significant crying of infantile colic adds stress to the infant and their family, yet it has no recognized etiology. Gastrointestinal health problems and dysfunction have been suspected in the etiology of colic. Disruptions to the microbiome colonization of the gastrointestinal system may lead to excess gas and inflammation that ...
Jessica M, Johnson, Ellise D, Adams
openaire   +4 more sources

Gut Microbiome and Gastrointestinal Disorders

2021
The human gut harbors more than 1014 microorganisms, with bacteria being the main population. Gut microbial composition and diversity participates in vital physiologic and immunologic processes maintaining host homeostasis. The disruption of the healthy microbial structure has been associated with various gastrointestinal disorders including ...
Legaki Evangelia, Eleni Anna Karanasou, Maria Gazouli   +2 more
openaire   +1 more source

Therapeutic implications of the gastrointestinal microbiome

Current Opinion in Pharmacology, 2018
Gut microbiome is an integral part of the metabolic machinery that contributes to normal host function. The advent of next generation sequencing technologies has allowed an in-depth investigation of the microbiome at various body sites including microbes which are challenging to culture. The same technologies have revealed the metabolic capacity of the
Purna C, Kashyap, Eamonn Mm, Quigley
openaire   +2 more sources