Results 281 to 290 of about 1,018,866 (382)

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

Advanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou, Wenli Zhao, Yihan Zhu, Hongyan Liu, Yicheng Sun, Zhengrong Gong, Xuanyi Li, Ziying Liu, Kang Wen, Yicheng Wang, Jie Ren, Ruipei Xiao, Ling Jiang, Yanfeng Hu, Enguang Bi, Xiaoyong Zhang   +15 more
wiley   +1 more source

Cytological Assessment of Metastatic Gastrointestinal Stromal Tumor in Ascitic Fluid. [PDF]

Diagn Cytopathol
Sultan H, Sadeghian Z, Goez-Gutierrez E, Diacovo MJ, Yoon E.   +4 more
europepmc   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Retrospective study of splenectomy specimens with clinical and pathological features in Southern Iran. [PDF]

Sci Rep
Soleimani N, Soleimani M, Jafari F, Mohammadzadeh S, Karajizadeh M.   +4 more
europepmc   +1 more source

CO52 | The impact of <i>KRAS</i> mutations on the risk of recurrent venous thromboembolism in patients with cancer-associated thrombosis and gastrointestinal neoplasms

openalex   +1 more source

Lutetium‐Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR‐II Fluorescence Imaging‐Guided Surgery in Colorectal Cancer

Advanced Science, EarlyView.
Enhancing radiosensitization, modulating the tumor immune microenvironment, and ensuring complete resection are crucial for colorectal cancer (CRC) treatment. This study presents a multifunctional NIR‐II fluorescent nanoprobe, RVLu@ICG, which enhances radiosensitization, remodels the tumor immune microenvironment, and enables precise image‐guided ...
Yongying Dang, Xianzhi Liu, Zifan Zheng, Ao Wang, Ying Huang, Zhong Luo, Haina Tian, Siyaqi Li, Qiang Luo, Peiyuan Wang, Weiling He   +10 more
wiley   +1 more source

Bibliometric analysis in Scopus of scientific production on the relationship between periodontitis and gastrointestinal cancer (2014 - 2023). [PDF]

Med Oral Patol Oral Cir Bucal
Asmat-Abanto AS, Portocarrero-Reyes A, Espejo-Carrera RE, Minchón-Medina CA, Timaná-Palacios DJ.   +4 more
europepmc   +1 more source

A39 IMPACT OF AN ENDOSCOPIC OPTICAL DIAGNOSIS COURSE ON GASTROINTESTINAL NEOPLASM CHARACTERIZATION SKILLS AMONG TRAINEE ENDOSCOPISTS

William T. Tran, Nikko Gimpaya, Rishad Khan, Catharine M. Walsh, Lawrence Hookey, Mandip Rai, Samir C. Grover, Robert Bechara   +7 more
openalex   +1 more source

Exploring Bacteria‐Based Cancer Immunotherapy: Comment on “Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics”

Advanced Science, EarlyView.
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source