Results 81 to 90 of about 57,177 (346)

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Percutaneous endoscopic gastrostomy for nutritional palliation of upper esophageal cancer unsuitable for esophageal stenting

Arquivos de Gastroenterologia, 2012
CONTEXT: Esophageal cancer is often diagnosed at an advanced stage and has a poor prognosis. Most patients with advanced esophageal cancer have significant dysphagia that contributes to weight loss and malnutrition.
Ana Grilo, Carla Adriana Santos, Jorge Fonseca   +2 more
doaj   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

Palliative Care and Dementia [PDF]

, 2006
This paper was commissioned by Alzheimer's Australia to promote discussion by people with dementia, their families and carers of the issues that may be faced as people with terminal dementia move towards death.
Jenny Abbey
core  

Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances [PDF]

, 2015
Background A number of conditions compromise the passage of food along the digestive tract. Nasogastric tube (NGT) feeding is a classic, time-proven technique, although its prolonged use can lead to complications such as lesions to the nasal wing ...
Abdel-Lah Mohamed, Aguilar-Nascimento, Anderson, Anis, Baeten, Barker, BarkmeierJM, Bastow, Bath, Bath, Beavan, Blumenstein, Botella Romero, Chiò, Corry, Dennis, Dennis, Dorman, Douzinas, Dwolatzky, Falsetti, Finestone, Fini, Friginal-Ruiz, Gauderer, Geeganage, Gentile, Gomes, Gomes, Gopalan, Granell Vidal, Grant, Hamidon, Heemskerk, Ho, Iwamoto, Kearns, Kolaček, Köhler, Langmore, Le, Ljungdahl, Löser, Löser, Manba, Marik, McClave, Mekhail, Metheny, Moher, Norton, Nugent, Ordoñez, Park, Pearce, Piecuch, Plonk, Poisson, Potack, Ramel, Scheeren, Schneider, Schröder, Schulz, Simons, Skitt, Stec, Stiegmann, Tucker, Valente da Silva, Wang, Wollman, Zaherah Mohamed Shah   +72 more
core   +1 more source

Postoperative and Functional Outcomes of Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate predictors of postoperative and functional outcomes following salvage oropharyngectomy. Methods In this single‐center retrospective study, we included all patients who underwent an oropharyngectomy in an irradiated neck for recurrent or metachronous cancer between 2014 and 2023. Results We included 94 patients.
Jade Saykaly, Agnès Dupret‐Bories, Sébastien Vergez, Virginie Woisard, Benjamin Vairel, Jérôme Sarini, Ana Cavillon, Emilien Chabrillac   +7 more
wiley   +1 more source

Toward a Typology of Patients With Head and Neck Cancer: Biopsychosocial Profiles Predicting Longitudinal Quality of Life

Head &Neck, EarlyView.
ABSTRACT Background Quality of life (QoL) in head and neck cancer (HNC) is influenced by complex biopsychosocial factors, yet few longitudinal studies have examined these relationships immediately post‐treatment. Methods In this prospective study, 232 patients newly diagnosed with primary HNC completed psychometric assessments, clinical interviews, and
Haley Deamond, Cyril Devault‐Tousignant, Jacob Lang, Christopher Lo, Jennifer Silver, Nader Sadeghi, Zeev Rosberger, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Gabrielle Chartier, Marco Mascarella, Khalil Sultanem, Georges Shenouda, Fabio Cury, Melissa Henry   +18 more
wiley   +1 more source

Francis F. Maury, M.D. (1840 to 1879): an often forgotten pioneer in early American surgery. [PDF]

, 2014
Francis F. Maury (Fig. 1) was born on August 9, 1840, in Danville, Kentucky, where he was raised on a farm by his mother and father. His father was an Episcopal clergyman of Huguenot descent, whose forefathers had fled from France to escape religious ...
Chevrollier, B.S., Guillaume S., Cowan, MD, Scott W., Kairys, MD, John C, Yeo, MD, Charles J.   +3 more
core   +1 more source

Comparación entre dos tipos de gastrostomías quirúrgicas, abierta y laparoscópica, en nutrición enteral domiciliaria [PDF]

, 2012
Objetivo: Exponer las complicaciones de las gastrostomías quirúrgicas utilizadas como vía de soporte nutricional enteral domiciliario (SNED) y detectar si existen diferencias entre las dos técnicas usadas en nuestro medio: Cirugía abierta vs ...
Alarcón del Agua, Isaías, García Luna, Pedro Pablo, Hisnard Cadet Dussort, J. M., Morales Conde, Salvador, Oliva Rodríguez, R., Parejo Campos, J., Pereira Cunill, José Luis, Serrano Aguayo, Pilar, Tous Romero, M. C.   +8 more
core   +2 more sources

Critical Appraisal of Pancreaticogastrostomy After Pancreatoduodenectomy: Evolution, Evidence, and Future Prospects

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Pancreaticogastrostomy (PG) emerged as a reconstructive option after pancreaticoduodenectomy (PD) due to its reported lower incidence of postoperative pancreatic fistula (POPF), but its superiority over pancreaticojejunostomy (PJ) remains unclear.
Samuel Menezes, Isabella R. Buonopane, Luís Felipe Leite, Anelise Poluboiarinov Cappellaro, Marcos Belotto   +4 more
wiley   +1 more source