Results 51 to 60 of about 42,197 (311)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effectiveness of gatekeepers' training for suicide prevention program among medical professionals and medical undergraduate students of a medical college from Western India

Industrial Psychiatry Journal, 2021
Introduction: Suicide risk among Indigenous populations is a multifaceted phenomenon, influenced by biological, psychological, and social factors at the individual level, as well as cultural, political, and economic issues at the family and community ...
Rutvin Patel, Ritambhara Mehta, Kamlesh Dave, Pradhyuman Chaudhary   +3 more
doaj   +1 more source

Structural differences between small gatekeeper ATP binding sites and large gatekeeper ATP binding sites.

, 2016
Structural differences form the basis for BKIs to selectively act on the Giardia kinases described in this study. (a) The ATP binding pocket of protein kinases typically contains a large amino acid gatekeeper residue (e.g. methionine).
Germain C. M. Alas (3328872), Tess R. Smith (3328878), Jennifer W. Xu (3328869), Kayode K. Ojo (353587), Ethan A. Merritt (544725), Alexander R. Paredez (3328881), Kelly M. Hennessey (3328875)   +6 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Impacto del entorno digital en los medios tradicionales chilenos: percepciones y actitudes predominantes de sus protagonistas

Palabra Clave, 2023
El artículo investiga las transformaciones provocadas por el entorno digital y las redes sociales dentro de las salas de redacción de medios tradicionales chilenos. Se enfoca en tres aristas: el impacto del entorno digital en el ejercicio del periodismo,
Rocío González-Trujillo, Catalina Olate-Hidalgo, Daniela Grassau   +2 more
doaj  

Exploring general practitioners’ perceptions about the primary care gatekeeper role in Indonesia

BMC Family Practice, 2021
Background In the current healthcare delivery system funded by National Health Insurance (NHI) in Indonesia, the gatekeeper role of primary care services is critical to ensuring equal healthcare access for the population.
Joko Mulyanto, Yudhi Wibowo, Dionne S. Kringos   +2 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Diagnostic utility of coronary artery calcium score percentiles and categories to exclude abnormal scans and relevant ischemia in rubidium positron emission tomography

Frontiers in Cardiovascular Medicine
BackgroundDespite clinical suspicion, most non-invasive ischemia tests for coronary artery disease (CAD) reveal unremarkable results. Patients with a coronary artery calcium score (CACS) of zero rarely have an abnormal positron emission tomography (PET ...
Simon M. Frey, Simon M. Frey, Gabrielle Huré, Jan-Philipp Leibfarth, Kathrin Thommen, Melissa Amrein, Klara Rumora, Ibrahim Schäfer, Federico Caobelli, Federico Caobelli, Damian Wild, Philip Haaf, Philip Haaf, Christian E. Mueller, Christian E. Mueller, Michael J. Zellweger, Michael J. Zellweger   +16 more
doaj   +1 more source

Nanoapplication of a Resistance Inducer to Reduce Phytophthora Disease in Pineapple (Ananas comosus L.)

Frontiers in Plant Science, 2019
Treatment of plants with a variety of abiotic and biotic inducers causes induced resistance to pathogen attack. In this study, the effect of four resistance inducers on plant diseases caused by Phytophthora cinnamomi was screened in vivo initially by ...
Xinhua Lu, Xinhua Lu, Dequan Sun, James E. Rookes, Lingxue Kong, Xiumei Zhang, David M. Cahill   +6 more
doaj   +1 more source

Gatekeeper Training for Suicide Prevention

, 2015
In recent years, the rising rate of suicides by military personnel has generated concern among policymakers, military leaders, and the public at large. Based on a recommendation from an earlier RAND report on preventing suicide among military personnel ...
Burnette, Crystal, Ramchand, Rajeev, Ayer, Lynsay   +2 more
core   +1 more source