Results 31 to 40 of about 8,936 (168)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

BOSNIAK CULTURAL HERITAGE: CULTURAL CHARACTERISTICS OF TRADITIONAL KNOCKERSAND GATES

Human Research in Rehabilitation, 2011
Culture, molding the attitude of one, creates social order and ensures social identity of the belonging community. When it comes to Bosnian, or more precisely Bosniak culture, it is of high importance to discuss traditional gates, which represent one ...
Yusuf Ziya Sümbüllü, Melinda Botalić
doaj   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Randomised benchmarking for universal qudit gates

New Journal of Physics
We aim to establish a scalable scheme for characterising diagonal non-Clifford gates for single- and multi-qudit systems; d is a prime-power integer. By employing cyclic operators and a qudit T gate, we generalise the dihedral benchmarking scheme for ...
David Amaro-Alcalá, Barry C Sanders, Hubert de Guise   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Typology and evolution of gates and access into early Hallstattian fortresses in Tisa-Dniester space / Tipologia şi evoluţia porţilor şi căilor de acces în cetăţile hallstattiene timpurii din spaţiul tiso-nistrean

Tyragetia, 2015
For the time interval between the second half of the 12th century BC and early 8th century BC, in the space between Tisa and Dniester Rivers have been discovered about 140 fortifications.
Aurel Zanoci
doaj  

Laser-free trapped ion entangling gates with AESE: adiabatic elimination of spin-motion entanglement

New Journal of Physics
We discuss a laser-free, two-qubit geometric phase gate technique for generating high-fidelity entanglement between two trapped ions. The scheme works by ramping the spin-dependent force on and off slowly relative to the gate detunings, which ...
R Tyler Sutherland, Michael Foss-Feig
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Experiences with rotavirus vaccines: can we improve rotavirus vaccine impact in developing countries?

Human Vaccines & Immunotherapeutics, 2019
Rotavirus vaccines have been introduced into over 95 countries globally and demonstrate substantial impact in reducing diarrheal mortality and diarrheal hospitalizations in young children.
A.D. Steele, J.C. Victor, M.E. Carey, J.E. Tate, D.E. Atherly, C. Pecenka, Z. Diaz, U.D. Parashar, C.D. Kirkwood   +8 more
doaj   +1 more source