Results 41 to 50 of about 1,016,504 (289)

The Shigella Vaccines Pipeline

open access: yesVaccines, 2022
Shigella is the leading cause of global diarrheal deaths that currently lacks a licensed vaccine. Shigellosis drives antimicrobial resistance and leads to economic impact through linear growth faltering.
Calman Alexander MacLennan   +3 more
doaj   +1 more source

Low-noise nozzle valve [PDF]

open access: yes, 1990
A low noise, variable discharage area, valve is constructed having opposed recesses within which a pair of gates are slidably disposed. Each of the gates is provided with upstream edges having a radius thereon, the radius enabling smooth, accelerated ...
Aaron, James, Gwin, Hal S.
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Qudit versions of the qubit "pi-over-eight" gate [PDF]

open access: yes, 2012
When visualised as an operation on the Bloch sphere, the qubit "pi-over-eight" gate corresponds to one-eighth of a complete rotation about the vertical axis.
A. Broadbent   +9 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Flow rate measurement in gravity irrigation systems using sluice gates

open access: yesAgrociencia Uruguay
Gates are used to divert water to rice production plots in eastern Uruguay. In this study, the operating curves of rectangular gates installed at the entrance of circular section pipes are determined for submerged discharge conditions, which can be also ...
Lisette Bentancor, Francisco Pedocchi
doaj   +1 more source

Preventing a cluster from becoming a new wave in settings with zero community COVID-19 cases

open access: yesBMC Infectious Diseases, 2022
Background In settings with zero community transmission, any new SARS-CoV-2 outbreaks are likely to be the result of random incursions. The level of restrictions in place at the time of the incursion is likely to considerably affect possible outbreak ...
Romesh G. Abeysuriya   +8 more
doaj   +1 more source

Implementation of universal quantum gates based on nonadiabatic geometric phases [PDF]

open access: yes, 2002
We propose an experimentally feasible scheme to achieve quantum computation based on nonadiabatic geometric phase shifts, in which a cyclic geometric phase is used to realize a set of universal quantum gates.
D. V. Averin   +7 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns [version 2; peer review: 2 approved]

open access: yesGates Open Research, 2022
Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services.
Brittany Hagedorn   +4 more
doaj   +1 more source

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