Results 41 to 50 of about 5,175,842 (164)

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain

Annals of Neurology, EarlyView.
Objective The objective of this study was to explore the association between 18 kDa translocator protein (TSPO)‐positron emission tomography (PET)–measurable glial activation and serum chitotriosidase (CHIT1) in people with multiple sclerosis (pwMS), and its expression in postmortem MS brain tissue.
Venla Ahola, Maija Saraste, Edoardo Pedrini, Joel Tuomaala, Luzia Buchholz, Markus Matilainen, Johanna Lindenberg, Eeva‐Christine Brockmann, Maria Sofia Martire, Sofia Sandgren, David Leppert, Jens Kuhle, Tanja Kuhlmann, Martina Absinta, Laura Airas   +14 more
wiley   +1 more source

Gaucher’s Disease in Lithuania: Its Diagnosis and Treatment

, 2011
Gaucher’s disease is a lysosomal storage disease caused by the lack of beta-glucocerebrosidase enzyme, leading to the accumulation of glucocerebroside. Gaucher’s disease is the most frequent type of sphingolipidosis as well as the most frequent lysosomal
Gražina Kleinotienė, Anna Tylki-Szymanska, Barbara Czartoryska   +2 more
core   +1 more source

Mitochondria and quality control defects in a mouse model of Gaucher Disease-links to Parkinson's Disease [PDF]

, 2013
Mutations in the glucocerebrosidase (gba) gene cause Gaucher disease (GD), the most common lysosomal storage disorder, and increase susceptibility to Parkinson's disease (PD).
Gegg, ME, Osellame, LD, Richard-Londt, A, Brandner, S, Hargreaves, IP, Waddington, SN, Schapira, AHV, Rahim, AA, Duchen, MR, Schapira, AH   +9 more
core   +1 more source

Failure of treatment of Coxa Vara in Gauchers Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2012
Gaucher’s disease (GD) is an autosomal recessive storage disorder which occurs due to the deficient functioning of the lysosomal hydrolase enzyme [1, 2]. In this case report, coxa vara occurred after the union of a stress fracture in the basicervical
Sachin Khullar, Atul Rajeshwar Bhasker, Mohamed Habeeb, Boragam Gangaraju   +3 more
doaj  

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Gaucher's disease with myocardial involvement in pregnancy

São Paulo Medical Journal, 2002
CONTEXT: Described originally in 1882, Gaucher's disease is the most prevalent of storage disorders. This autosomal recessive disease is caused by a defective gene responsible for coding the beta-glucosidase enzyme, essential in the hydrolysis of ...
Maria Regina Torloni, Kátia Franco, Nelson Sass   +2 more
doaj   +1 more source

Osteoarticular pathology in Gaucher disease, complicated by tuberculosis (clinical observations)

Гений oртопедии, 2022
Introduction Gaucher disease belongs to the group of hereditary lysosomal orphan cumulative diseases caused by deficiency of the β-glucocerebrosidase enzyme. It features polysystemic affection, including bone tissue. The osteoarticular system in Gaucher
Lyudmila A. Semenova, Vladimir A. Khomenko, Kira A. Lukina   +2 more
doaj   +1 more source

A Solid‐Phase Approach to Chiral C2‐Substituted Cyclen and DOTA‐Like Lanthanoid Ligands

Chemistry – A European Journal, EarlyView.
Chiral C2‐substituted cyclen derivatives have been designed and synthesized from chiral cyclic peptoids. Their conversion into the corresponding DOTA‐type ligands opens new avenues for the development of high‐relaxivity MRI contrast agents. ABSTRACT Magnetic resonance imaging (MRI) is a powerful diagnostic modality that relies on Gd+3‐based contrast ...
Rosaria Schettini, Roberta Napolitano, Alberto Fringuello Mingo, Federica Buonsanti, Giovanni Pierri, Consiglia Tedesco, Chiara Costabile, Giorgio Della Sala, Irene Izzo, Francesco De Riccardis   +9 more
wiley   +1 more source

Chemical engineering as an essential element of industrial biotechnology in Mexico: New aims in research and university education

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía, Octavio T. Ramírez, Rafael Vazquez‐Duhalt, Eduardo Bárzana   +3 more
wiley   +1 more source

Gaucher's disease: a case report [PDF]

, 2017
Gaucher's disease (GD) is an autosomal recessive disorder, characterized by lack of acid β-glucosidase (glucocerebrosidase) enzyme resulting in accumulation of glucosylceramide in different organs.
Rameshwar Ninama, Bhupesh Jain, Jain, Bhupesh, Ninama, Rameshwar, Goyal, Suresh, Singla, Sanjay, Sanjay Singla, Suresh Goyal   +7 more
core   +1 more source