Results 111 to 120 of about 28,810 (212)

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Treatment options for patients with Gaucher disease

Egyptian Journal of Medical Human Genetics, 2016
Gaucher disease is the most common lysosomal storage disorder due to deficiency of ß-glucocerebrosidase. Since the introduction of Ceredase in 1991, enzyme replacement therapy has been the mainstay of treatment with its major disadvantage of long life ...
Rabah M. Shawky, Solaf M. Elsayed
doaj   +1 more source

What Is a Digital Twin in QSP, and Are We Doing It Right?

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The field of Quantitative Systems Pharmacology continues to innovate new methods to derive insights from clinical data. In the past few years, Digital Twins have emerged as a “new” way of deriving patient‐specific model parameterizations to inform possible outcomes for novel scenarios using limited clinical data.
Justin Feigelman
wiley   +1 more source

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management

The Journal of Dermatology, Volume 53, Issue 3, Page 380-387, March 2026.
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Takashi Sakai
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Welcome Pathogens: Transient Heat Dampens Immune Responses to Acibenzolar‐S‐Methyl in Apple Plants

Plant, Cell &Environment, Volume 49, Issue 3, Page 1229-1248, March 2026.
ABSTRACT Climate change affects plant‐pathogen interactions, with disease outcome varying depending on the pathosystem and environmental scenario. In Arabidopsis, a thermo‐sensitive module of salicylic acid (SA) signalling makes immunity vulnerable to heat.
Erwan Chavonet, Bao‐huynh Nguyen, Christelle Heintz, Raphaël Cournol, Jitka Široká, Ondřej Novák, Romain Larbat, Matthieu Gaucher, Marie‐Noëlle Brisset, Florent Pantin, Alexandre Degrave   +10 more
wiley   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Gaucher disease: A 10 year old girl with anemia and huge spelenomegaly (a case report)

, 2008
Gaucher's disease is a rare lipid storage disorder, affecting one in 40,000-200,000 people and results from a genetic deficiency of the enzyme glucocerebrosidase (glucosylceramidase).
Davarian, A., Mirbehbahani, N.B.
core   +1 more source

Similarities and differences in carotid artery, hemodynamic, and autonomic reactivity induced by mental stress or cold in adults: A randomized crossover study

Physiological Reports, Volume 14, Issue 5, March 2026.
The Stroop test and cold pressor test elicit comparable common carotid artery vasodilation. However, mental stress induced by the Stroop test leads to an earlier peak response, possibly influenced by anticipatory mechanisms. Created in BioRender. Speretta, G. (2026) https://BioRender.com/mwpc1hw.
Francisco J. Fensterseifer, Iara G. Teixeira, Welliton Oracz, Richard E. Filipini, Francine Stein, Guilherme F. Speretta   +5 more
wiley   +1 more source

Necrosis avascular de cabeza femoral en pacientes con enfermedad de Gaucher tipo I : tratamiento mediante artroplastia total de cadera no cementada [PDF]

, 2017
El 80% de los pacientes con enfermedad de Gaucher presentan manifestaciones óseas, siendo la necrosis avascular de la cabeza femoral una de las que mayor limitación produce y la primera causa de intervención quirúrgica osteoarticular.
Blas Dobón, J.A., López Vega, Marcos, Pelayo de Tomás, José Manuel, Rodrigo Pérez, José Luís, Valero Fabado, H.   +4 more
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