Results 11 to 20 of about 538 (112)

Polygenic Risk Scores for Amyloidosis as Predictors of Early changes in Alzheimer's Disease Endophenotypes [PDF]

Alzheimers Dement
Abstract Background Early identification of individuals at risk for Alzheimer's disease (AD) is critical for effective intervention. Amyloid deposition, a hallmark of AD pathology, offers insights into genetic factors driving disease progression. While the APOE genotype is a major contributor, the role of other risk variants in amyloid deposition and ...
Xu Y, Qiao M, Gunasekaran T, Gu Y, Reyes‐Dumeyer D, Piriz A, Sanchez D, Soriano B, Franco Y, Coronado Z, Recio P, Mejia D, Medrano M, Lantigua R, Reyes R, Wilson R, Manly J, Brickman A, Engelman C, Johnson S, Asthana S, Vardarajan B, Mayeux R.   +22 more
europepmc   +2 more sources

Polygenic scores of Core 1 Alzheimer's disease biomarkers predict early cognitive and pathological change. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Core 1 biomarkers, such as amyloid positron emission tomography, capture the earliest biological changes leading to Alzheimer's disease (AD). While APOE is a major genetic factor, the contribution of other variants to Core 1 biomarkers remains unclear.
Xu Y, Qiao M, Gunasekaran TI, Gu Y, Reyes-Dumeyer D, Piriz A, Sanchez D, Soriano B, Franco Y, Coronado ZD, Recio P, Mejia DR, Medrano M, Lantigua RA, Honig L, Wilson R, Manly JJ, Brickman AM, Engelman CD, Johnson S, Asthana S, Vardarajan B, Mayeux R.   +22 more
europepmc   +2 more sources

GAUDI: interpretable multi-omics integration with UMAP embeddings and density-based clustering [PDF]

Nature Communications
Integrating high-dimensional cellular multi-omics data is crucial for understanding various layers of biological control. Single ‘omic methods provide important insights, but often fall short in handling the complex relationships between genes, proteins,
Pol Castellano-Escuder, Derek K. Zachman, Kevin Han, Matthey D. Hirschey   +3 more
doaj   +2 more sources

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI [PDF]

Nature Communications
Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for ...
Quan Sun, Bryce T. Rowland, Jiawen Chen, Anna V. Mikhaylova, Christy Avery, Ulrike Peters, Jessica Lundin, Tara Matise, Steve Buyske, Ran Tao, Rasika A. Mathias, Alexander P. Reiner, Paul L. Auer, Nancy J. Cox, Charles Kooperberg, Timothy A. Thornton, Laura M. Raffield, Yun Li   +17 more
doaj   +2 more sources

The German Auditory and Image (GAudI) vocabulary test: A new German receptive vocabulary test and its relationships to other tests measuring linguistic experience. [PDF]

PLoS ONE
Humans acquire word knowledge through producing and comprehending spoken and written language. Word learning continues into adulthood and knowledge accumulates across the lifespan. Therefore, receptive vocabulary size is often conceived of as a proxy for
Sandra Bethke, Antje S Meyer, Florian Hintz   +2 more
doaj   +2 more sources

Temporoparietal Scalp Intravenous Schwannoma: Rare Subcutaneous Soft Tissue Mass in an Unusual Location [PDF]

Case Reports in Surgery
Schwannomas, or neurilemmomas, are benign nerve sheath tumors of Schwann cell origin, sometimes associated with neurofibromatosis type 2 (NF2) and schwannomatosis. Intravenous schwannomas are exceedingly rare, pose diagnostic challenges due to their unusual location within blood vessels and lack of surrounding perineurium.
Haymete M, Fitzgerald A, Gay J, Tershak D, Eden K, Grider D.   +5 more
europepmc   +2 more sources

Topology optimization considering self‐weight

Proceedings in Applied Mathematics and Mechanics, Volume 23, Issue 4, December 2023., 2023
Abstract In civil engineering self‐weight loading usually represents the preponderant load case and shall therefore be considered in structural optimization. The present study investigates numerical topology optimization of structural stiffness with a bound on disposable amount of material. A customized topology optimization routine based on Sequential
Daniela Masarczyk, Detlef Kuhl
wiley   +1 more source

La inacabada iglesia de la Colonia Güell. Qué había que hacer con ella

Informes de la Construccion, 2002
Promovida por el Consorcio de la Colonia Güell, propietario actual del edificio, la restauración de la iglesia está siendo ejecutada por el Servicio de Patrimonio Arquitectónico Local de la Diputación de Barcelona que, siguiendo su habitual método de ...
Antoni González Moreno-Navarro
doaj   +1 more source

Philosophy of Contemporary Environmental Design in view of Antonio Gaudi Artifacts

Journal of Architecture, Art & Humanistic Science, 2018
Recently we can find several environmental design concepts, which raises controversy about identifying its meanings, principles and elements. This research can be considered as a contribution to identify and clear the right concept of the term ...
Eman AL Banna, Mohamed Saad
doaj   +1 more source

Gaudí and the reinvention of the architectural order

ArcHistoR Architettura Storia Restauro: Architecture History Restoration, 2016
The term "re-invention", used in the title, draws suggestion from the article Gli ordini architettonici rinascita o invenzione? (The Architectural Order Revival or Invention?).
Simonetta Ciranna
doaj   +1 more source