Results 111 to 120 of about 805,376 (284)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A superspace formulation of the BV action

, 1994
We show that the BV (Batalin Vilkovisky) action, formulated with an extended BRST symmetry (including the shift symmetry), is also invariant under an extended anti-BRST transformation (where the antifields are the parameters of the transformation), when ...
Alfaro, Alfaro, Alfaro, Ashok Das, Batalin, Batalin, Batalin, Batalin, Batalin, Baulieu, Becchi, Bonora, Curci, Das, Das, Ferrara, Fujikawa, Gomis, Grégoire, Grégoire, Henneaux, Nelson R.F. Braga, Troost, Tyutin   +23 more
core   +1 more source

Gauge fixing the SU(N) lattice-gauge-field Hamiltonian [PDF]

Physical Review D, 1985
We exactly gauge fix the Hamiltonian for the SU(N) lattice gauge field and eliminate the redundant gauge degrees of freedom. The gauge-fixed lattice Hamiltonian, in particular for the Coulomb gauge, has many new terms in addition to the ones obtained in the continuum formulation.
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Hodge gauge fixing in three dimensions

, 1996
A progress report on experiences with a gauge fixing method proposed in LATTICE 94 is presented. In this algorithm, an SU(N) operator is diagonalized at each site, followed by gauge fixing the diagonal (Cartan) part of the links to Coulomb gauge using ...
Hetrick, James E.
core   +2 more sources

Equivariant gauge fixing of SU(2) lattice gauge theory [PDF]

Physical Review D, 1998
46 pages, Latex, updated and shortened version to appear in Phys.Rev ...
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Triplectic Gauge Fixing for N=1 Super Yang-Mills Theory

, 2001
The Sp(2)-gauge fixing of N = 1 super-Yang-Mills theory is considered here. We thereby apply the triplectic scheme, where two classes of gauge-fixing bosons are introduced.
E. M. C. Abreu, I. A. Batalin, I. A. Batalin, I. A. Batalin, I. A. Batalin, I. A. Batalin, I. A. Batalin, I. A. Batalin, I. Batalin, Kazuo Fujikawa, M. Henneaux, M. Henneaux, Nelson R. F. Braga, P. Grégoire, P. Grégoire, P. Grégoire, W. Troost   +16 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Gribov copies, avalanches and dynamic generation of a gluon mass

, 2017
Analytic calculations in the infrared regime of nonabelian gauge theories are hampered by the presence of Gribov copies which results in some ambiguity in the gauge-fixing procedure.
Tissier, Matthieu
core   +1 more source