Results 151 to 160 of about 1,473,724 (341)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Invariability Conditions of Motion Equations of non-Abelian Gauge Fields and Elimination of Higgs Mechanism [PDF]

open access: yesarXiv, 2005
It is proved that in order to keep both the Lagrangian and the motion equation of non-Abelian gauge fields unchanged under the gauge transformation simultaneously, a certain restriction conditions should be established between the gauge potentials and the group parameters. The result is equivalent to the Faddeev--Popov theory.
arxiv  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Gauge Theory of Gravity [PDF]

open access: yesarXiv, 2001
The quantum gravity is formulated based on principle of local gauge invariance. The model discussed in this paper has local gravitational gauge symmetry and gravitational field appears as gauge field. The problems on quantization and renormalization of the theory are also discussed in this paper.
arxiv  

Mesoscopic glass transition model: Influence of the cooling rate on the structure refinement

open access: yesAIMS Mathematics
The process of glass transition during the quenching in the domain with the cold wall has been numerically simulated. We have implemented the temperature-dependent form of the previously proposed theoretical model, which combined the heat transfer in the
Vladimir Ankudinov   +2 more
doaj   +1 more source

Implications of gauge theories for heavy leptons [PDF]

open access: green, 1975
Carl H. Albright   +2 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Anatomy of a gauge theory

open access: yesAnnals of Physics, 2006
We exhibit the role of Hochschild cohomology in quantum field theory with particular emphasis on gauge theory and Dyson--Schwinger equations, the quantum equations of motion. These equations emerge from Hopf- and Lie algebra theory and free quantum field theory only.
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

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