Results 161 to 170 of about 6,887,067 (387)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Finite BRST Mapping in Higher Derivative Models

open access: yes, 2017
We continue the study of finite field dependent BRST (FFBRST) symmetry in the quantum theory of gauge fields. An expression for the Jacobian of path integral measure is presented, depending on a finite field-dependent parameter, and the FFBRST symmetry ...
Castro, Ricardo A.   +2 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Freezing and BPS jumping

open access: yesJournal of High Energy Physics
We report a novel BPS jumping phenomenon of 5d N $$ \mathcal{N} $$ = 1 supersymmetric gauge theories whose brane configuration is equipped with an O7-plane.
Sung-Soo Kim   +3 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

A Gauge Field Theory for Continuous Spin Tachyons

open access: yes, 2018
We present a gauge field theory for unitary infinite dimensional tachyonic representations of the Poincar\'e group. It was obtained by a dimensional reduction from the gauge field theory for continuous spin particles in a cotangent bundle over Minkowski ...
Rivelles, Victor O.
core  

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