Results 181 to 190 of about 7,058,876 (385)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Supercooled confinement

open access: yesJournal of High Energy Physics
We study general properties of confinement phase transitions in the early universe. An observable gravitational wave signal from such transitions requires significant supercooling.
Prateek Agrawal   +3 more
doaj   +1 more source

Mesoscopic glass transition model: Influence of the cooling rate on the structure refinement

open access: yesAIMS Mathematics
The process of glass transition during the quenching in the domain with the cold wall has been numerically simulated. We have implemented the temperature-dependent form of the previously proposed theoretical model, which combined the heat transfer in the
Vladimir Ankudinov   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Analyticity of the Free Energy of a Closed 3-Manifold

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2008
The free energy of a closed 3-manifold is a 2-parameter formal power series which encodes the perturbative Chern-Simons invariant (also known as the LMO invariant) of a closed 3-manifold with gauge group U(N) for arbitrary N.
Stavros Garoufalidis   +2 more
doaj   +1 more source

GAUGE GRAVITATION THEORY [PDF]

open access: yes, 1992
G Sardanashvily, O Zakharov
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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