Results 201 to 210 of about 358 (259)
Transformation of the Agrarian Landscape and Hope in the Central Kalimantan Peatlands
Asia Pacific Viewpoint, EarlyView.ABSTRACT In Kalimantan, Indonesian Borneo, agrarian state programs and corporate strategies seek to transform indigenous Ngaju Dayak into sedentary farmers. Focusing on the notion of transformation, the paper traces whether and how rural people can engage in struggles against structural injustices.
Anu Lounela
wiley +1 more source
Impact of climate on Australian, non‐Vector‐borne infectious animal diseases: A scoping review
Australian Veterinary Journal, EarlyView.Changes to Australia's climate continue to be increasingly relevant for human, animal and planetary health, and have far‐reaching impacts on disease emergence and food security. There is a deficit of knowledge in Australia around how climatic conditions are affecting infectious animal diseases, beyond the more obvious spatial distribution changes of ...
G Terry, MP Ward
wiley +1 more source
British Journal of Educational Psychology, EarlyView.Abstract Background While skill development is generally linked to relevant practice, the 2022 PISA creative thinking report revealed a negative association between students' creative thinking performance and their engagement in creative activities. Aims This study explored whether this negative association was linear, persisted across countries and ...
Sofiia Kagan, Denis Dumas, Yoojoong Kim
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah +7 more
wiley +1 more source
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, EarlyView.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source
Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia
British Journal of Pharmacology, EarlyView.Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais +4 more
wiley +1 more source
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