A marginal estimate for the overall treatment effect on a survival outcome within the joint modeling framework. [PDF]
Joint models for longitudinal and survival data are increasingly used and enjoy a wide range of application areas. In this article, we focus on the application of joint models on clinical trial data with special interest in the treatment effect on the survival outcome.
van Oudenhoven FM +3 more
europepmc +2 more sources
Validation of a Longitudinal Marker as a Surrogate Using Mediation Analysis and Joint Modeling: Evolution of the PSA as a Surrogate of the Disease-Free Survival. [PDF]
ABSTRACT Longitudinal biomarkers constitute a broad class of potential surrogate endpoints in clinical trials. Several approaches have been proposed for surrogate validation but available methods for validating a longitudinal biomarker as a surrogate of a time‐to‐event endpoint such as death remain limited.
Le Coent Q +3 more
europepmc +2 more sources
Average treatment effects on binary outcomes with stochastic covariates. [PDF]
Abstract When evaluating the effect of psychological treatments on a dichotomous outcome variable in a randomized controlled trial (RCT), covariate adjustment using logistic regression models is often applied. In the presence of covariates, average marginal effects (AMEs) are often preferred over odds ratios, as AMEs yield a clearer substantive and ...
Kiefer C +3 more
europepmc +2 more sources
A Location-Scale Joint Model for Studying the Link Between the Time-Dependent Subject-Specific Variability of Blood Pressure and Competing Events. [PDF]
ABSTRACT Given the high incidence of cardio and cerebrovascular diseases (CVD), and their association with morbidity and mortality, their prevention is a major public health issue. A high level of blood pressure is a well‐known risk factor for these events, and an increasing number of studies suggest that blood pressure variability may also be an ...
Courcoul L +4 more
europepmc +2 more sources
We analyze a nonlinear integral equation for calculating free‐surface divergence that was proposed by Szeri (2017, https://doi.org/10.1002/2016JC012312). When given the temperature and heat flux at a free surface, the surface divergence can be calculated through a nonlinear singular Volterra‐type integral equation.
Tianyi Li, Andrew J. Szeri, Lian Shen
wiley +1 more source
Abstract In this article, we assess farms’ technical efficiency accounting for their production heterogeneity and correcting for the potential endogeneity associated with the adoption of Common Agricultural Policy (CAP) agri‐environmental schemes (AESs). We estimate a first‐step selection probit model.
K Hervé Dakpo +3 more
wiley +1 more source
Dilatancy Toughening of Shear Cracks and Implications for Slow Rupture Propagation
Abstract Dilatancy associated with fault slip produces a transient pore pressure drop which increases frictional strength. This effect is analyzed in a steadily propagating rupture model that includes frictional weakening, slip‐dependent fault dilation and fluid flow.
Nicolas Brantut
wiley +1 more source
On the Flux Linkage between Pancake Coils in Resonance‐Type Wireless Power Transfer Systems
This work presents a series representation for the mutual inductance of two coaxial pancake coils which remains accurate in non‐quasi‐static regime under the hypothesis that the current in the source coil is uniformly distributed. Making use of Gegenbauer’s addition theorem and a term‐by‐term analytical integration, the mutual inductance between two ...
Mauro Parise +3 more
wiley +1 more source
Individualized dynamic prediction of survival with the presence of intermediate events
Often, in follow‐up studies, patients experience intermediate events, such as reinterventions or adverse events, which directly affect the shapes of their longitudinal profiles. Our work is motivated by two studies in which such intermediate events have been recorded during follow‐up. In both studies, we are interested in the change of the longitudinal
Grigorios Papageorgiou +3 more
wiley +1 more source
Galileo Ionospheric Correction Algorithm: An Optimization Study of NeQuick‐G
Abstract At present most low‐cost GNSS receivers operate one frequency in the L band. For them one of the largest error contributions is the delay of radio signals in the Ionosphere. NeQuick‐G is the official ionospheric correction algorithm (ICA), which has been adopted for Galileo, the European GNSS Programme.
A. Aragon‐Angel +2 more
wiley +1 more source

