Results 41 to 50 of about 88,242 (260)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Study on driver’s turning intention recognition hybrid model of GHMM and GGAP-RBF neural network

Advances in Mechanical Engineering, 2018
The accuracy and real time are crucial in turning intention recognition. Therefore, a hybrid model of Gaussian mixture hidden Markov and generalized growing and pruning algorithm for radial basis function neural network is constructed to recognize driver
Shu Wang, Qiang Yu, Xuan Zhao
doaj   +1 more source

Prediction of operating dynamics in floating-zone crystal growth using Gaussian mixture model

Science and Technology of Advanced Materials: Methods, 2022
We have applied a Gaussian mixture regression to the prediction of operation dynamics in floating zone crystal growth as an example of a materials process.
R. Omae, S. Sumitani, Y. Tosa, S. Harada
doaj   +1 more source

On the Reversible Jump Markov Chain Monte Carlo (RJMCMC) Algorithm for Extreme Value Mixture Distribution as a Location-Scale Transformation of the Weibull Distribution

Applied Sciences, 2021
Data with a multimodal pattern can be analyzed using a mixture model. In a mixture model, the most important step is the determination of the number of mixture components, because finding the correct number of mixture components will reduce the error of ...
Dwi Rantini, Nur Iriawan, Irhamah
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Federated Gaussian Mixture Models

CoRR
This paper introduces FedGenGMM, a novel one-shot federated learning approach for Gaussian Mixture Models (GMM) tailored for unsupervised learning scenarios. In federated learning (FL), where multiple decentralized clients collaboratively train models without sharing raw data, significant challenges include statistical heterogeneity, high communication
Sophia Zhang Pettersson, Kuo-Yun Liang, Juan Carlos Andresen   +2 more
openaire   +2 more sources

Gaussian Mixture Modeling with Gaussian Process Latent Variable Models [PDF]

, 2010
11 pages, 2 figures, 3 ...
Nickisch, H., Rasmussen, C.
openaire   +4 more sources

Anchored Bayesian Gaussian mixture models

Electronic Journal of Statistics, 2020
Finite mixtures are a flexible modeling tool for irregularly shaped densities and samples from heterogeneous populations. When modeling with mixtures using an exchangeable prior on the component features, the component labels are arbitrary and are indistinguishable in posterior analysis.
Kunkel, Deborah, Peruggia, Mario
openaire   +4 more sources