Results 51 to 60 of about 2,250,983 (287)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sexual Health and Stigma in Urban Newspaper Coverage of Methamphetamine

American Journal of Men's Health, 2008
The epidemic use of methamphetamine in the United States is a growing public health problem. Recently its use has increased among gay men who live in urban areas, with accompanying increases in sexually transmitted diseases.
Joseph Schwartz MA, Julie L. Andsager PhD   +1 more
doaj   +1 more source

Preference for Male Facial Masculinity as a Function of Mental Rotation Ability in Gay and Bisexual Men, but Not in Heterosexual Men and Women in China

Frontiers in Psychology, 2019
This study examined the association between mental rotation ability and facial masculinity preference in gay and bisexual men in China. The participants (436 gay/bisexual men, 132 heterosexual men, and 254 heterosexual women) completed an online Shepard ...
Lijun Zheng
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Development and Validation of the Gay-Specific Intraminority Stigma Inventory (G-SISI): Initial Evidence Underpinned by Intraminority Stress Theory

European Journal of Investigation in Health, Psychology and Education, 2023
There is currently a lack of measures testing intraminority stress within gay men. Therefore, the current study sought to develop and psychometrically test the Gay-Specific Intraminority Stigma Inventory (G-SISI).
Benjamin F. Shepherd, Justin L. Maki, David G. Zelaya, Şeniz Warner, Adriana Wilson, Paula M. Brochu   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Folder 6: A: Folder 5, January, 1989

, 1989
Booklet for the Southeastern Conference for Lesbians and Gay Men calling for applicants for presentations for the ...
Southeastern Conference for Lesbians and Gay Men
core   +5 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Friends with Benefits, but without the Sex: Straight Women and Gay Men Exchange Trustworthy Mating Advice

Evolutionary Psychology, 2013
Although research has made progress in elucidating the benefits exchanged within same- and opposite-sex friendships formed between heterosexual men and women, it is less clear why straight women and gay men form close relationships with one another.
Eric M. Russell, Danielle J. DelPriore, Max E. Butterfield, Sarah E. Hill   +3 more
doaj   +1 more source

Male homosexuality and borderline personality disorder: a review [PDF]

Journal of Men's Health
Gay and bisexual men are more likely than heterosexual men to be diagnosed with borderline personality disorder (BPD). Evidence also suggests an elevated presence of mental health issues and psychological difficulties among gay and bisexual men.
Jaiyant Cavale, Dweep Chand Singh, Lata Hemchand   +2 more
doaj   +1 more source