Results 101 to 110 of about 25,632 (110)

High-Relaxivity Molecular MRI Contrast Agent to Target Gb3-Expressing Cancer Cells.

Bioconjugate chemistry, 2022
Targeted contrast agents (CAs) can improve magnetic resonance imaging (MRI) for accurate cancer diagnosis. In this work, we used the Shiga toxin B-subunit (STxB) as a targeting agent, which binds to Gb3, a glycosphingolipid highly overexpressed on the ...
S. Deville-Foillard, Anne-Marie Billet, Rose-Marie Dubuisson, L. Johannes, P. Durand, Frédéric Schmidt, A. Volk   +6 more
semanticscholar   +1 more source

Multiscale Molecular Dynamics Studies Reveal Different Modes of Receptor Clustering by Gb3-Binding Lectins.

Journal of Chemical Theory and Computation, 2021
The recognition of carbohydrate receptors on host cell membranes by pathogenic lectins is a crucial step in the microbial invasion. Two bacterial lectins, the B-subunit of Shiga toxin from Shigella dysenteria (StxB) and lectin I from Pseudomonas ...
Raisa Kociurzynski, Olga N. Makshakova, V. Knecht, W. Römer   +3 more
semanticscholar   +1 more source

Accuracy diagnosis improvement of Fabry disease from dried blood spots: Enzyme activity, lyso‐Gb3 accumulation and GLA gene sequencing

Clinical Genetics, 2021
The purpose of this study was to examine the applicability of the use of samples in dried blood spot (DBS) for the definitive diagnosis of Fabry disease (FD) in males and females and to compare the diagnostic role of α‐galactosidase A activity (α‐Gal A),
Rocío Delarosa-Rodríguez, J. D. Santotoribio, Paula Hernández-Arévalo, A. Gónzalez-Meneses, S. García-Morillo, P. Jiménez-Arriscado, J. Guerrero, H. Macher   +7 more
semanticscholar   +1 more source

Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility.

American Journal of Physiology - Gastrointestinal and Liver Physiology
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by a deficiency in α-galactosidase A leading to the accumulation of globotriaosylceramide (Gb3) and subsequent increase in globotriaosylsphingosine (lyso-Gb3) in different cells and ...
C. Delprete, Friederike H. Uhlig, Marco Caprini, N. P. Hyland   +3 more
semanticscholar   +1 more source

Globotriaosylsphingosine (lyso-Gb3) and analogues in plasma and urine of patients with Fabry disease and correlations with long-term treatment and genotypes in a nationwide female Danish cohort

Journal of Medical Genetics, 2020
Introduction Recent studies showed the usefulness of globotriaosylsphingosine (lyso-Gb3) and related analogues, deacylated forms of globotriaosylceramide (Gb3), for high-risk screening, treatment monitoring and follow-up for patients with Fabry disease ...
G. Effraimidis, U. Feldt-Rasmussen, Å. Rasmussen, P. Lavoie, Mona Abaoui, M. Boutin, C. Auray-Blais   +6 more
semanticscholar   +1 more source

Compatibility analysis of UAS terrestrial CNPC links and MLS in the 5030–5091 MHz band

2022 IEEE 6th Information Technology and Mechatronics Engineering Conference (ITOEC), 2022
Cui Kaitao, Ye Jiaquan, Liu Rui, Zou Jie, Gao Jing   +4 more
semanticscholar   +1 more source

One of the two N-glycans on the human Gb3/CD77 synthase is essential for its activity and allosterically regulates its function.

Biochemical and Biophysical Research Communications - BBRC, 2022
Krzysztof Mikołajczyk, M. Sikora, Cyril Hanus, R. Kaczmarek, M. Czerwinski   +4 more
semanticscholar   +1 more source

The use and performance of lyso-Gb3 for the diagnosis and monitoring of Fabry disease: A systematic literature review.

Molecular Genetics and Metabolism
U. Ramaswami, Michael L West, K. Tylee, G. Castillon, Andreas Braun, Megan Ren, I. Doobaree, Heena Howitt, Albina Nowak   +8 more
semanticscholar   +1 more source

On-Site Food Toxin Detection System Using a Gb3-Immobilized Microchip and a Portable Fluorescence Sensing System

BioChip Journal
Keying Li, Jeongtae Kim, Yujin Jeong, Moo-Seung Lee, Chiwan Koo   +4 more
semanticscholar   +1 more source

Globotriaosylsphingosine (Lyso-Gb3) as a biomarker for cardiac variant (N215S) Fabry disease

Journal of Inherited Metabolic Disease, 2018
Fahad J. Alharbi, S. Baig, C. Auray-Blais, M. Boutin, D. Ward, N. Wheeldon, Rick Steed, C. Dawson, D. Hughes, T. Geberhiwot   +9 more
semanticscholar   +1 more source