Results 101 to 110 of about 28,529 (123)

Multiscale Molecular Dynamics Studies Reveal Different Modes of Receptor Clustering by Gb3-Binding Lectins.

Journal of Chemical Theory and Computation, 2021
The recognition of carbohydrate receptors on host cell membranes by pathogenic lectins is a crucial step in the microbial invasion. Two bacterial lectins, the B-subunit of Shiga toxin from Shigella dysenteria (StxB) and lectin I from Pseudomonas ...
R. Kociurzynski, Olga N. Makshakova, V. Knecht, W. Römer   +3 more
semanticscholar   +1 more source

Accuracy diagnosis improvement of Fabry disease from dried blood spots: Enzyme activity, lyso‐Gb3 accumulation and GLA gene sequencing

Clinical Genetics, 2021
The purpose of this study was to examine the applicability of the use of samples in dried blood spot (DBS) for the definitive diagnosis of Fabry disease (FD) in males and females and to compare the diagnostic role of α‐galactosidase A activity (α‐Gal A),
Rocío Delarosa-Rodríguez, J. D. Santotoribio, Hernández-Arévalo Paula, A. Gónzalez-Meneses, S. García-Morillo, P. Jiménez-Arriscado, J. Guerrero, H. Macher   +7 more
semanticscholar   +1 more source

Correlation of Lyso-Gb3 levels in dried blood spots and sera from patients with classic and Later-Onset Fabry disease

Molecular Genetics and Metabolism, 2017
Robert Desnick, Albina Nowak, Thomas Mechtler   +2 more
exaly   +2 more sources

The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection

Virulence, 2020
Bacillus cereus is an opportunistic pathogen that can cause emetic or diarrheal foodborne illness. Previous studies have identified multiple pathogenic B. cereus strains and characterized a variety of virulence factors.
Yongqiang Jiang, Huaijie Hao, Hua Jiang   +2 more
exaly   +2 more sources

Lyso-Gb3 Increases αvβ3 Integrin Gene Expression in Cultured Human Podocytes in Fabry Nephropathy

Journal of Clinical Medicine, 2020
Background: Podocyturia in Fabry nephropathy leads to glomerulosclerosis and kidney disease progression. Integrins are involved in podocyte attachment to the glomerular basement membrane. We hypothesized that in Fabry nephropathy, lyso-Gb3 could modulate
Maria Dolores Sanchez-Niño, Hernán Trimarchi, Alberto Ortiz Arduan   +2 more
exaly   +2 more sources

SHIGA TOXINS FROM ENTEROHEMORRHAGIC ESCHERICHIA COLI AND ANTI-GB3 ANTIBODY AS NOVEL AGENTS AGAINST TRIPLE NEGATIVE BREAST CANCER.

Chemico-Biological Interactions
Shiga toxins (Stx) are potent bacterial exotoxins and the main virulence factor of enterohemorrhagic Escherichia coli. Stx have ribotoxic activity in eukaryotic target cells of the mammalian host by recognizing its globotriaosylceramide receptor (Gb3 ...
A. Pinto, N. Miret, Ana Belen Ramos Aloi, Florencia Vassallu, Lionel M. Igaz, A. Randi, J. Goldstein   +6 more
semanticscholar   +1 more source

Discovery and design of an aptamer that inhibits Shiga toxin type 2 activity by blocking Stx2 B subunit-Gb3 interaction.

International Journal of Biological Macromolecules
Shiga toxin (Stx) is the definitive virulence factor of Stx-producing Escherichia coli. This bacterial pathogen can contaminate food and threaten human health.
Mengxia Duan, Kexin Ren, Xiaowan Chen, Yuting Chang, Ziyu Lv, Zhou-Ping Wang, Shi-Jia Wu, Nuo Duan   +7 more
semanticscholar   +1 more source

Mass cytometry reveals atypical immune profile notably impaired maturation of memory CD4 T with Gb3‐related CD27 expression in CD4 T cells in Fabry disease

Journal of Inherited Metabolic Disease
Fabry disease (FD) is an X‐linked disease characterized by an accumulation of glycosphingolipids, notably of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lysoGb3) leading to renal failure, cardiomyopathy, and cerebral strokes.
W. Mauhin, G. Dzangué-Tchoupou, D. Amelin, A. Corneau, F. Lamari, Y. Allenbach, Bertrand Dussol, V. Leguy-Seguin, Pauline D'Halluin, M. Matignon, François Maillot, K. Ly, Gérard Besson, M. Willems, F. Labombarda, A. Masseau, C. Lavigne, Didier Lacombe, H. Maillard, O. Lidove, O. Benveniste   +20 more
semanticscholar   +1 more source

Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility.

American Journal of Physiology - Gastrointestinal and Liver Physiology
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by a deficiency in α-galactosidase A leading to the accumulation of globotriaosylceramide (Gb3) and subsequent increase in globotriaosylsphingosine (lyso-Gb3) in different cells and ...
C. Delprete, Friederike H. Uhlig, M. Caprini, N. P. Hyland   +3 more
semanticscholar   +1 more source

Globotriaosylsphingosine (lyso-Gb3) and analogues in plasma and urine of patients with Fabry disease and correlations with long-term treatment and genotypes in a nationwide female Danish cohort

Journal of Medical Genetics, 2020
Introduction Recent studies showed the usefulness of globotriaosylsphingosine (lyso-Gb3) and related analogues, deacylated forms of globotriaosylceramide (Gb3), for high-risk screening, treatment monitoring and follow-up for patients with Fabry disease ...
G. Effraimidis, U. Feldt-Rasmussen, Å. Rasmussen, P. Lavoie, Mona Abaoui, Michel Boutin, C. Auray-Blais   +6 more
semanticscholar   +1 more source