Results 151 to 160 of about 111,100 (299)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden   +3 more
wiley   +1 more source

MAFF Suppresses Necroptosis in Pancreatic Cancer via the GATA4‐MLKL Axis

open access: yesCancer Science, EarlyView.
MAFF promotes pancreatic cancer progression by acting as a transcriptional repressor of the GATA4‐MLKL axis, thereby inhibiting necroptotic cell death. This study identifies the MAFF‐GATA4‐MLKL pathway as a novel therapeutic target and a significant prognostic biomarker for pancreatic adenocarcinoma.
Xinwei Zhou   +3 more
wiley   +1 more source

Validation of the German version of Infants and Toddlers Dermatology Quality of Life (InToDermQoL) Questionnaire

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Skin diseases can greatly impair quality of life (QoL) of pediatric patients and their families. The Infants and Toddlers Dermatology Quality of Life questionnaire (InToDermQoL) is the first skin‐generic instrument assessing QoL in children ≤ 4 years, as reported by their caregiver. This study aimed to psychometrically
Juliane Traxler   +8 more
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

open access: yesThe FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova   +12 more
wiley   +1 more source

Challenges and Future Trends in Large Vessel Vasculitis. [PDF]

open access: yesCirculation
Sandovici M   +12 more
europepmc   +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

open access: yesHIV Medicine, EarlyView.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria   +555 more
wiley   +1 more source

[<sup>68</sup>Ga]Ga-DOTA-Siglec-9 PET/CT in newly diagnosed giant cell arteritis: an inflammation-specific, treatment-responsive molecular imaging biomarker. [PDF]

open access: yesRMD Open
Petzinna SM   +13 more
europepmc   +1 more source

Barriers and Facilitators for Caregivers Providing Involuntary Oral Care to Individuals With Dementia: A Qualitative Literature Review

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To assess barriers and facilitators for caregivers providing involuntary oral care to individuals with dementia. Methods A qualitative review was performed. Due to the scarcity of studies on involuntary oral care provision, the strategy to reach the aim was to identify barriers and facilitators for providing involuntary care in ...
M. Jonker, C. Engelsma, A. Visser
wiley   +1 more source

Aortitis accelerates the growth rate of thoracic aortic aneurysms. [PDF]

open access: yesRMD Open
Benichou A   +11 more
europepmc   +1 more source

Experience of Australian rheumatologists managing polymyalgia rheumatica: results from a national survey

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background Polymyalgia rheumatica is the commonest inflammatory condition affecting adults over 50 years of age, however it has been under‐researched and management varies in everyday clinical practice. Aim This national survey of rheumatologists and trainees managing polymyalgia rheumatica (PMR) in Australia sought to determine current ...
Jessica L. Leung   +8 more
wiley   +1 more source
sca
combining ability
heterosis
giant cell arteritis
line x tester
cotton
gene action
high energy physics - theory
3. good health
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