Results 221 to 230 of about 40,634 (335)

Detecting early memory changes in preclinical Alzheimer's disease using TabCAT favorites test: Data from the European Prevention of Alzheimer's Disease (EPAD) cohort

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sensitive memory paradigms may allow the detection of subtle memory changes associated with early Alzheimer's pathology in individuals without established clinical symptomatology. METHODS We explored the cross‐sectional association between performance on Tablet‐based Cognitive Assessment Tool (TabCAT) Favorites, a brief ...
Anna Brugulat‐Serrat, Elena Tsoy, Gonzalo Sánchez‐Benavides, Marta Milà‐Alomà, Leslie S. Gaynor, Oriol Grau‐Rivera, Juan Domingo Gispert, Joel H Kramer, Katherine L Possin, for the European Prevention of Alzheimer's Disease (EPAD) Consortium   +9 more
wiley   +1 more source

An exploration and analysis of the role positioning, duty comparison, and career development path of clinical research nurses in developed and developing countries. [PDF]

Front Med (Lausanne)
Cao X, Xu J, Li M, Zheng L.
europepmc   +1 more source

Decoding Causal Associations Between Neuropsychiatric Disorders and Rotator Cuff Tendinopathy: A Two‐Sample Mendelian Randomization Study

Brain and Behavior, Volume 16, Issue 2, February 2026.
Key findings from our study revealed that ADHD and PTSD are independent genetic risk factors for RCT in European populations after ruling out potential influence from body shape, lifestyle, socioeconomic status, and physical activity intensity Abstract Background Rotator cuff tendinopathy (RCT) is a major contributor to over 30 million surgeries which ...
Weizhe Zhang, Ming Chen, Haozhang Huang, Puyi Sheng   +3 more
wiley   +1 more source

Rapid and Accurate Diagnosis of Breast Cancer by Fine‐Needle Aspiration Biopsy Using the “Click‐to‐Sense” Method

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background We have previously demonstrated the value of the “click‐to‐sense” (CTS) assay, in which a fluorescent probe targeting acrolein can detect cancer cells and differentiate between malignant and benign lesions in breast tissue. In this study, we assessed the usefulness of the CTS assay for diagnosis of breast tumors by fine‐needle ...
Yuri Kitahara, Tomonori Tanei, Takaaki Hatano, Ambara R. Pradipta, Koji Morimoto, Tadasuke Nagatomo, Kaori Abe, Nanae Masunaga, Chieko Mishima, Tetsuhiro Yoshinami, Masami Tsukabe, Yoshiaki Sota, Tomohiro Miyake, Masafumi Shimoda, Yuichi Motoyama, Eiichi Morii, Katsunori Tanaka, Kenzo Shimazu   +17 more
wiley   +1 more source

Establishing a clinical trial site: A primer for aspiring principal investigators. [PDF]

Contemp Clin Trials Commun
Sramek JJ, Carrillo MS, Cutler NR.
europepmc   +1 more source

GCP(案)の早期実現を望む(新薬の臨床試験の実施をめぐって)

, 1988
Hisao Yoshizawa
openalex   +1 more source

A comparative pharmacokinetic evaluation of two aqueous progesterone 25 mg injections in healthy postmenopausal women under fasting conditions: An open‐label, balanced, randomized, two‐treatment, two‐period, two‐sequence, single‐dose, crossover bioequivalence study

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract The growing demand for assisted reproductive technology (ART) has increased the need for effective luteal phase support. Progesterone, essential for maintaining early pregnancy, is a critical component of ART. This open‐label, balanced, randomized, two‐treatment, crossover, single‐dose study compared the bioequivalence of aqueous progesterone ...
Noopur Vyas, Amaresh Chakra, Prashant Sarode, Shruti Dharmadhikari, Gaurav Puppalwar, Chintan Khandhedia, Amey Mane, Alpesh Goyani, Ajay Jaysingh Khopade   +8 more
wiley   +1 more source

Association of Follicular Distribution Patterns in Polycystic Ovaries with Clinical Outcomes in Assisted Reproductive Technology Cycles: A Prospective Cohort Study. [PDF]

Int J Fertil Steril
Farid Mojtahedi M, Alemohammad F, Moini A, Kashani L, Khodarahmian M, Ramezanali F, Ghasemi F, Shahhosseini R.   +7 more
europepmc   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Phase 1 Study of Firsekibart in Chinese Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract Firsekibart is an anti‐IL‐1β monoclonal antibody for treating acute gout flares in adults. This randomized, double‐blind, placebo‐controlled study assessed the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of multiple ascending doses of firsekibart in healthy Chinese adults.
Xiaolan Yong, Xiaolin Du, Xiao Li, Yushi Chen, Xiaoyan Zhu, Tianhong Luo, Qian Xu   +6 more
wiley   +1 more source

Evolving Standards: Good Clinical Practice Insights from US FDA, MHRA UK, and Health Canada. [PDF]

Clin Pharmacol Ther
Grandinetti C, Budwal-Jagait M, Abid H, Gebbia E, Boley E, Williams L, Fisher A, Marcus L, Muldowney L, Sellers J, Wakelin-Smith J, Ayalew K.   +11 more
europepmc   +1 more source