Results 231 to 240 of about 40,634 (335)

tetnakao/NGS-PCA: Add GCP streaming capabilities

jlanej
openalex   +1 more source

Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 381-392, February 2026.
Model‐informed precision dosing (MIPD) of tacrolimus in renal allograft recipients, evaluated in silico, demonstrated improved (time to and) probability of target concentration attainment and smaller deviations from target range. Using simulated tacrolimus concentration‐time profiles, a study of 200 patients was predicted to have sufficient power to ...
Dirk R.J. Kuypers, Pieter Annaert, Borefore Jallah, Maarten Naesens, Maxine Teuns, Annouschka Laenen, Ruben Faelens   +6 more
wiley   +1 more source

Long-term evolutionary persistence of a cryptic color polymorphism in frogs. [PDF]

Proc Natl Acad Sci U S A
Goutte S, Boissinot S.
europepmc   +1 more source

Large Language Models for Clinical Trial Protocol Assessments

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 393-402, February 2026.
The purpose was to evaluate the utility of large language models (LLMs) for reviewing the statistical analysis plan (SAP) and pharmacokinetics–pharmacodynamics (PK–PD) components of clinical trial protocols. Clinical trial protocols and SAPs were obtained from clinicaltrials.gov for a testbed of 15 small‐molecule drugs, biologics, and global antibiotic
Euibeom Shin, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Live-attenuated foot-and-mouth disease virus vaccine engineered by codon deoptimization induces a strong protective immune response in cattle. [PDF]

NPJ Vaccines
Attreed SE, Silva C, Rodriguez-Calzada M, Heimroth RD, Oldakowski M, Stenfeldt C, Azzinaro P, Spinard E, Mogulothu A, Mueller S, Taillon B, Arzt J, Rieder E, de Los Santos T, Díaz-San Segundo F, Medina GN.   +15 more
europepmc   +1 more source

An Evaluation of the Drug Interaction Potential of Encorafenib in Combination With Binimetinib Using the Inje Cocktail in Patients With Cancer

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 375-380, February 2026.
A clinical drug–drug interaction (DDI) study was designed to evaluate the effect of single and multiple oral doses of encorafenib on the single oral dose pharmacokinetics (PK) of the cytochrome P450 (CYP) enzyme probe substrates, losartan (CYP2C9), midazolam (CYP3A4), caffeine (CYP1A2), omeprazole (CYP2C19), and dextromethorphan (CYP2D6) administered ...
Joseph Piscitelli, Micaela B. Reddy, Lance Wollenberg, Laurence Del Frari, Jason Gong, Kyle Matschke, Jason H. Williams   +6 more
wiley   +1 more source

The Transformative Effect of Training on Informed Consent: A Comparative Study Among Medical Postgraduate Researchers. [PDF]

Cureus
Mirza MA, Suravaram S, Siddiqui IA.
europepmc   +1 more source

Pharmacists' Knowledge of Non-Sterile Good Compounding Practice (GCP) and Its Implementation in Balikpapan Community Health Centers: A Cross-Sectional Study

Devindy Arsita Rusmawantia, Heri Wijaya, Gayatri Citraningtyas, Ali Almubarak   +3 more
openalex   +2 more sources

Ruxolitinib Suppresses Interferon‐γ‐Induced JAK/STAT Activation in Oral Keratinocytes

Clinical and Experimental Dental Research, Volume 12, Issue 1, February 2026.
ABSTRACT Objectives The Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway plays a crucial role in oral inflammatory diseases such as oral lichen planus (OLP) and periodontitis. Interferon‐gamma (IFN‐γ) is a cytokine that activates the JAK/STAT pathway.
Kim N. Stolte, Anna Fedorova, Sameh Attia, Kerstin Danker, Henrik Dommisch   +4 more
wiley   +1 more source

Robust Angio-Vasculogenic Properties of 3D-Cultured Dual GCP-2/PDGF-β Gene-Edited Human ASCs. [PDF]

Int J Mol Sci
Han S, An SJ, Kim SW.
europepmc   +1 more source