Results 31 to 40 of about 4,112 (266)
Neural Development, 2019 Background The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule ...
Alexandre Wojcinski +4 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli +11 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes +10 more
wiley +1 more source
Plant Methods, 2018 Background Guard cell protoplasts (GCPs) isolated from various plants have proven to be especially useful for studies of signal transduction pathways and plant development.
Xuehui Yao +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria +4 more
wiley +1 more source
Drones, 2022 Unmanned aerial vehicles (UAVs) can obtain high-resolution topography data flexibly and efficiently at low cost. However, the georeferencing process involves the use of ground control points (GCPs), which limits time and cost effectiveness.
Xiaoyu Liu +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert +6 more
wiley +1 more source
Nano ExpressThis study was designed to develop a nanogel formulation incorporating acyclovir and lignocaine (ALN). Various formulations were developed in which ALN-V (formulation-V) was optimized.
Adnan Aslam +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts +6 more
wiley +1 more source
Geocarto InternationalGridded climate products (GCPs) play a vital role in hydro-climatic modeling by overcoming the limitations of gauge data. This study compares the performance of the recently launched NASA POWER and ERA5-Land, with CHIRPS and APHRODITE, in simulating ...
Hongrong Du +3 more
doaj +1 more source