Results 181 to 190 of about 4,132 (265)

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2607-2623, August 2026.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria   +4 more
wiley   +1 more source

Impact of Atrial Fibrillation on the Risk of Thrombosis and Bleeding for Patients With Polycythemia Vera and Essential Thrombocytosis in the Real World

open access: yes
American Journal of Hematology, Volume 101, Issue 9, Page 2463-2468, September 2026.
Rodrigo Ortega Perez   +19 more
wiley   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2672-2681, August 2026.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert   +6 more
wiley   +1 more source

Uncertainty of Object Points Monoplotted from Terrestrial Images. [PDF]

open access: yesJ Photogramm Remote Sens Geoinform Sci
Mikolka-Flöry S, Ressl C, Pfeifer N.
europepmc   +1 more source

Selective Anti‐Inflammatory Actions of Curcumin on Cytokine Pathways in Major Depressive Disorder

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
Curcumin partially attenuates IRS/M1/Th1 immune activation in MDD patients ex vivo, but fails to normalize it. Paradoxically, it upregulates immune profiles in healthy controls. Its immunomodulatory effects are state‐dependent, suggesting cautious use in non‐depressed individuals.
Tangcong Chen   +6 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell   +13 more
wiley   +1 more source

Monocytes Display Altered Inflammatory Profiles in Individuals with Diabetic Foot Ulcers Indicating Monocyte Dysfunction

open access: yesEuropean Journal of Immunology, Volume 56, Issue 8, August 2026.
Monocytes display an altered inflammatory profile in individuals with DFU, indicating dysfunctional monocytes. The downregulation of both inflammatory and anti‐inflammatory markers, together with increased production of pro‐inflammatory cytokines, suggests the presence of low‐grade inflammation and dysregulated monocyte activation, which may impair ...
Rekha Marimuthu   +7 more
wiley   +1 more source

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