Results 31 to 40 of about 4,123 (263)
Neural Development, 2019 Background The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule ...
Alexandre Wojcinski +4 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective To assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients 2–17 years with active pcJIA and inadequate response ...
Hermine I Brunner +28 more
wiley +1 more source
Implementing GCPs in Asia [PDF]
The Quality Assurance Journal, 2000 The implementation of International Conference on Harmonization (ICH)-Good Clinical Practice (GCP) standards in China, Taiwan, Thailand and Japan poses some unique challenges due to cultural influences, particularly in Japan. Auditing experiences were generally positive in all countries with auditing by a Western company being viewed as a positive and ...
openaire +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The shortage of trained clinical assessors in African National Regulatory Authorities (NRAs) poses a challenge to effective regulatory decision‐making. Developed in line with the World Health Organization's (WHO) Global Competency Framework (WHO‐GCF), a university‐certified short course, Dossier assessment for clinical assessors in Africa, was ...
Stephanie Leigh +19 more
wiley +1 more source
Plant Methods, 2018 Background Guard cell protoplasts (GCPs) isolated from various plants have proven to be especially useful for studies of signal transduction pathways and plant development.
Xuehui Yao +5 more
doaj +1 more source
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Nano ExpressThis study was designed to develop a nanogel formulation incorporating acyclovir and lignocaine (ALN). Various formulations were developed in which ALN-V (formulation-V) was optimized.
Adnan Aslam +3 more
doaj +1 more source
MULTI-SCALE MATCHING FOR THE AUTOMATIC LOCATION OF CONTROL POINTS IN LARGE SCALE AERIAL IMAGES USING TERRESTRIAL SCENES [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014 A technique to automatically locate Ground Control Points (GCPs) in large aerial images is presented considering the availability of low accuracy direct georeferencing data. The approach is based on image chips of GCPs extracted from vertical terrestrial
A. Berveglieri, A. M. G. Tommaselli
doaj +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT This study examines the influence of circular economy practices, as a manifestation of corporate social responsibility, on green value co‐creation and its subsequent effects on green collaborative practices and sustainable supply chain integration between providers and customers.
Adriana Santos +2 more
wiley +1 more source