Results 51 to 60 of about 13,846 (123)

Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson‐Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation

Aging Cell, Volume 25, Issue 8, August 2026.
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre, Jesús Alejandro Reyes‐Martínez, Juan Unzueta, Francisco Guevara‐Namorado, Solangy Lizcano‐Meneses, Susana Gonzalo, Angel Baldan, Claudia Rangel, Gerardo J. Alanis‐Funes, Francisco Garcia‐Sierra, Kevin Ruiz‐Fajardo, Simon Gormes‐Pinchanski, Susana Castro‐Obregón, Aranza Meza‐Dorantes, Rocio Alejandra Chavez‐Santoscoy, Isabel Arrieta‐Cruz, Paola Tristán‐Aburto, Jonathan J. Magaña, Bulmaro Cisneros   +18 more
wiley   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

El estudio de la biodiversidad en la era de la secuenciación masiva

Revista Mexicana de Biodiversidad, 2015
Recientemente se han desarrollado nuevas tecnologías de secuenciación masiva, conocidas comosecuenciación de siguiente generación (NGS, por sus siglas en inglés). Estas tecnologías permiten secuenciaciónrápida, masiva y a bajo costo de regiones genómicas
Ana E. Escalante, Lev Jardón Barbolla, Santiago Ramírez-Barahona, Luis E. Eguiarte   +3 more
doaj   +1 more source

Assessing differences among elasmobranch nurseries to aid conservation based on a genomics framework

Conservation Biology, Volume 40, Issue 4, August 2026.
Abstract Elasmobranch nurseries often differ in environmental conditions, demographics, and use patterns. These differences affect the distribution of genetic variation among nurseries. However, conservation and management strategies often fail to account for such differences because they are difficult to characterize.
Dominic G. Swift, Amanda M. Barker, William B. Driggers III, Bryan S. Frazier, Douglas H. Adams, James J. Gelsleichter, Dana M. Bethea, Bethany M. Deacy, David S. Portnoy   +8 more
wiley   +1 more source

Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropods

Conservation Biology, Volume 40, Issue 4, August 2026.
Abstract Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices.
E. Portanier, A. Tran Lu Y, F. Pradillon, C. Daguin‐Thiébaut, S. Ruault, P. Collins, E. Omnes, S. Fuchs, J. Carlsson, D. Jollivet, M. Matabos   +10 more
wiley   +1 more source

The genetic architecture of leaf vein density and its importance for photosynthesis in maize

New Phytologist, Volume 251, Issue 4, Page 1738-1754, August 2026.
Vein types in maize leaves. Summary Leaf venation density has significantly increased during plant evolution. Higher densities are observed in angiosperms compared with early land plants, and among angiosperms, recently diverged C4 species have the highest values.
José Luis Coyac‐Rodríguez, Sergio Pérez‐Limón, Elizabeth Hernández‐Jaimes, Marcela Hernández‐Coronado, Daniel Camo‐Escobar, Ana Laura Alonso‐Nieves, María de Jesús Ortega‐Estrada, Nicole Gómez‐Capetillo, Ruairidh J. H. Sawers, Carlos Ortiz‐Ramírez   +9 more
wiley   +1 more source

Contribución de la genética moderna al desarrollo de la reprogramación celular Contribution of current genetics to development of cellular reprogramming

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2010
El avance en el conocimiento de la genética y en especial de la biología molecular, dio paso a una nueva era: la genómica, y a nuevos conceptos como transcriptoma, proteoma, metaboloma, epigenoma, que permiten el estudio de la estructura, organización y ...
Kalia Lavaut-Sánchez, Porfirio Hernández-Ramírez   +1 more
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Genómica del síndrome de Down

Acta Pediátrica de México, 2016
El síndrome de Down es la cromosomopatía más común del ser humano, con una frecuencia de 1 en 650 recién nacidos vivos. Las manifestaciones clínicas son muy variables y dependen, en gran parte, de la presencia de diversos factores genéticos como ...
S Díaz Cuéllar, E Yokoyama Rebollar, V del Castillo Ruiz   +2 more
doaj   +1 more source

Avanços recentes em nutrição de larvas de peixes Recent advances in nutrition of fish larval

Revista Brasileira de Zootecnia, 2009
Os requisitos nutricionais de larvas de peixes são ainda mal compreendidos, o que leva a altas mortalidades e problemas de qualidade no seu cultivo. Este trabalho pretende fazer uma revisão de novas metodologias de investigação, tais como estudos com ...
Luís Eugénio Castanheira da Conceição, Cláudia Aragão, Nadège Richard, Sofia Engrola, Paulo Gavaia, Sara Mira, Jorge Dias   +6 more
doaj   +1 more source

Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders

Revista Finlay
Neurodevelopmental disorders group conditions in which the growth and development of the brain is altered. This can damage both the neurocognitive and behavioral spheres such as the development of language, emotions, behavior, self-control, learning and ...
José Ignacio Lao Villadóniga
doaj