Results 141 to 150 of about 2,191,460 (344)

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

open access: yesAdvanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen   +13 more
wiley   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

open access: yesAdvanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang   +13 more
wiley   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang   +16 more
wiley   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

open access: yesAdvanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen   +14 more
wiley   +1 more source

Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings

open access: yesAdvanced Science, EarlyView.
Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini   +5 more
wiley   +1 more source

Nuclear Spin‐Free 70Ge/28Si70Ge Quantum Well Heterostructures Grown on Industrial SiGe‐Buffered Wafers

open access: yesAdvanced Science, EarlyView.
Hyperfine coupling to 29Si$^{29}{\rm Si}$ and 73Ge$^{73}{\rm Ge}$ nuclear spins limits hole spin‐qubit coherence in Ge heterostructures. We demonstrate device‐grade, nuclear‐spin‐free 70Ge$^{70}{\rm Ge}$/28Si70Ge$^{28}{\rm Si}^{70}{\rm Ge}$ quantum wells grown on industrial SiGe buffers with minimal use of enriched precursors.
Patrick Daoust   +11 more
wiley   +1 more source

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