Results 41 to 50 of about 773,997 (285)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Positioning justice: a legal cascade of sexual violence cases in Mombasa, Kenya

Frontiers in Global Women's Health
IntroductionSeeking legal redress for sexual violence (SV) is a daunting process for survivors. They must navigate their personal trauma societal stigma, and flawed systems, creating an arduous path to justice. This study was conducted to assess patterns
Melanie Olum, Gerald Githinji, Abigael Sidi, Abel Mokua, Morris Kiio, Nawal Aliyan, Iqbal Khandwala, Celina Kithinji, Saida Wanjiku, Griffins Manguro, Marleen Temmerman, Marleen Temmerman, Marleen Temmerman, Marleen Temmerman   +13 more
doaj   +1 more source

Factor Influencing Gender Based Violence Among Pregnant Women Attending Antenatal Clinic in PHC of Syangja District, Nepal [PDF]

, 2015
Pregnancy and childbirth were a time of unique vulnerability to violence victimization because of changes in women’s physical, social, emotional, and economic needs during pregnancy.
Acharya, J. (Jeevan), Gurung, S. (Samjhana)   +1 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Child marriage practice in the eyes of evangelical church leader and elders in the Wonisho district of the Sidama region, Southern Ethiopia

Humanities & Social Sciences Communications
Despite regional government initiatives and development agency efforts, child marriage remains deeply entrenched in Ethiopia, underscoring the need for sustained intervention.
Turufat Tukura, Sibilo Gashure
doaj   +1 more source

The Complexity of Defining Institutional Change in Academia

Social Inclusion
In recent decades, the European research and innovation landscape has shifted from addressing gender inequality by focusing on “fixing women” to prioritising “fixing the institution,” with gender equality plans (GEPs) as the primary tool for ...
Fernanda Campanini Vilhena, María López Belloso, María Silvestre Cabrera   +2 more
doaj   +1 more source

Characteristics of gender violence at the University of Valencia [PDF]

, 2014
The present study attempted to determine the prevalence of gender-based violence at the University of Valencia, the victim profile, resources, and beliefs about violence in the university community.
Belén Mora Valero, Francisco González Sala   +1 more
core   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Marriage, Violence, and Choice:Understanding Dalit women's agency in rural Tamil Nadu [PDF]

, 2014
Literature on Dalit women largely deals with issues of violence and oppression based on intersections of class, caste and gender. Women’s bodies, sexuality and reproductive choices are linked to the ideological hegemony of the caste-gender nexus in India,
Rao, Nitya
core   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

Advanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao, Chao Ren, Li‐Yu Zheng, Jing‐Yan Li, Wen‐Feng Wu, Yu‐Xuan Li, Li‐Xue Wang, Yu Duan, Lu Wang, Shuang‐Qing Liu, Peng‐Yi He, Peng‐Yue Zhao, Sen Tong, Zhi‐Xuan Li, Tuo Zhang, Meng‐Yao Wu, Shu‐Ting Wei, Ning Dong, Yao Wu, Hui Zhang, Xiao‐Mei Zhu, Zi‐Cheng Zhang, Guo‐Sheng Wu, Zhao‐Fan Xia, Xiao‐Hui Du, Hong‐Jun Kang, Zui Zou, Dao‐Lin Tang, Yong‐Ming Yao   +28 more
wiley   +1 more source