Results 121 to 130 of about 4,234,320 (260)

GnRH analogs as a monotherapy in transgender and gender-diverse adolescents: clinical insights from a single-center study

Endocrine Connections
Background: Gonadotropin-releasing hormone agonists (GnRHas) are widely used in the treatment of transgender and gender-diverse adolescents to prevent the development of undesired physical changes.
Fleur A H Lahaije, Petra A van Setten, Willemien Levels, Karlijn Becking-Malpasso, Hedi L Claahsen-van der Grinten   +4 more
doaj   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Primary care provider beliefs and knowledge of prescribing gender-affirming hormone therapy to transgender and gender diverse patients

BMC Primary Care
Background Transgender patients often cannot access a provider who is knowledgeable about providing gender-affirming hormone therapy (GAHT). This study evaluated primary care provider (PCP) comfort and experience with, opinions about, and knowledge of ...
Allison T. Yip, Stacy Charat, Jordan Silva, Jill Blumenthal   +3 more
doaj   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

Generations and Gender Survey (GGS) - Wave 2

The Generations and Gender Survey (GGS) is an individual-level survey which aims to improve understanding of family life, such as partnership formation and dissolution, fertility and intergenerational solidarity. The GGS provides detailed information on:
Generations and Gender Programme
core   +1 more source

Exploring upper limb musculoskeletal symptoms after gender-affirming top surgery: a cross-sectional survey

BMC Musculoskeletal Disorders
Background Transgender and gender diverse (TGD) people may undergo gender-affirming top surgery to align their physical appearance with their gender identity. While these procedures are known to improve psychosocial well-being, their musculoskeletal (MSK)
Angelica E. Lang, Sarah A. Fitzgerald, Meaghan Ray Peters, Brenna Bath, Tracey Carr, Soo Y. Kim   +5 more
doaj   +1 more source

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

Efficacy and feasibility of a telehealth intervention (Empowered Relief) for reducing pain-related discouraging thoughts and emotions for gender-diverse adults prior to surgery: protocol for a randomized controlled trial

BMC Surgery
Background Individuals that identify as transgender or gender diverse (TGD) are more likely to experience chronic pain that impacts quality of life. Chronic pain is a known risk factor for suboptimal post-surgical pain control and outcomes (Rosenberger ...
Jenna W. Stapleton, Siri H. Bohacek, Mair Marsiglio, Jenna E. Kachmarik, James W. Carson   +4 more
doaj   +1 more source

Psychometric validation of the Italian Gender Preoccupation and Stability Questionnaire in a gender-diverse clinical sample

BJPsych Open
Background Understanding gender identity in transgender and gender-diverse (TGD) individuals is crucial for effective care. The Gender Preoccupation and Stability Questionnaire (GPSQ) measures the preoccupation and stability of gender identity, but no ...
Paolo Meneguzzo, David Dal Brun, Alberto Scala, Marina Bonato, Andrea Garolla, Marina Miscioscia, Elena Tenconi, Angela Favaro   +7 more
doaj   +1 more source