Results 161 to 170 of about 7,281,565 (431)

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang   +9 more
wiley   +1 more source

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh   +8 more
wiley   +1 more source

Gender-affirming medical treatment for adolescents: a critical reflection on “effective” treatment outcomes

open access: yesBMC Medical Ethics
Background The scrutiny surrounding gender-affirming medical treatment (GAMT) for youth has increased, particularly concerning the limited evidence on long-term treatment outcomes.
Ezra D. Oosthoek   +4 more
doaj   +1 more source

Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling   +6 more
wiley   +1 more source

From 'Showgirls' to 'Performers': Fine-tuning with Gender-inclusive Language for Bias Reduction in LLMs [PDF]

open access: yesarXiv
Gender bias is not only prevalent in Large Language Models (LLMs) and their training data, but also firmly ingrained into the structural aspects of language itself. Therefore, adapting linguistic structures within LLM training data to promote gender-inclusivity can make gender representations within the model more inclusive.
arxiv  

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink

open access: yesArthritis Care &Research, EarlyView.
Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur   +5 more
wiley   +1 more source

“It's Just Good Science”: A Qualitative Study Exploring Equity, Diversity, and Inclusion in Canadian Arthritis Research

open access: yesArthritis Care &Research, EarlyView.
Objective Despite knowledge that health outcomes vary according to patient characteristics, identity, and geography, including underrepresented populations in arthritis research remains a challenge. We conducted interviews to explore how researchers in arthritis have used equity, diversity, and inclusion (EDI) principles to inform their research ...
Megan M. Thomas   +8 more
wiley   +1 more source

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