Results 221 to 230 of about 7,281,565 (431)

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

We Gon' Be Alright: Examining Culturally Relevant Coping Strategies as Promotive Factors for Black Romantic Relationships. [PDF]

Fam Process
Jenkins AIC, Rice TM, Smith SM, Barton AW, Beach SRH.   +4 more
europepmc   +1 more source

Review of Dominant Beliefs and Alternative Voices. Discourse, Belief, and Gender in American Study Abroad

, 1969
David Reyero
openalex   +2 more sources

Nonrandom Assignment of Loanwords: German Noun Gender [PDF]

, 1970
Walter Arndt
openalex   +1 more source

TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway

Advanced Science, EarlyView.
This study reveals the tumor‐suppressive role of TRIM38 in colorectal cancer (CRC). TRIM38 is downregulated through DNA hypermethylation and correlates with unfavorable clinical features and poor prognosis. Mechanistically, TRIM38 inhibits CRC progression by promoting K48‐linked ubiquitination of CCT6A, leading to the destabilization of c‐Myc.
Yue Zhang, Xinyu Tan, Lu Wang, Dongjian Ji, Chuan Zhang, Wen Peng, Renzhong Zhu, Xiaowei Wang, Jiahui Zhou, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Improving gender equity in academia depends on the workplace environment. [PDF]

Elife
Bhadra S, Damasceno G, Hoss D, Weyrich A.   +3 more
europepmc   +1 more source

Review of Unfinished Agendas: New and Continuing Gender Challenges in Higher Education

, 1969
Theresa Shanahan
openalex   +2 more sources

Cost‐Effective Identification of Hepatocellular Carcinoma from Cirrhosis or Chronic Hepatitis Virus Infection Using Eight Methylated Plasma DNA Markers

Advanced Science, EarlyView.
Early detection of hepatocellular carcinoma in patients with liver cirrhosis and/or hepatitis virus B/C infection improves survival. Through marker discovery, 8 methylated DNA markers are identified and a logistic regression model (COMET‐LR) is built in the training set, which achieved 90.0% sensitivity at 97.4% specificity in the validation set.
Tian Yang, Mingda Wang, Nanya Wang, Mingxin Pan, Yu Xu, Qiancheng You, Lanqing Yao, Jiahao Xu, Lihui Gu, Xiaodong Sun, Lei Zhang, Jiayue Xu, Bingsi Li, Guoqiang Wang, Shangli Cai, Guoyue Lv, Feng Shen   +16 more
wiley   +1 more source

Author reply to McDonough. [PDF]

Intern Med J
Nolan BJ, Cheung AS.
europepmc   +1 more source

“Spartacus’s wife, a woman who came from the same tribe as Spartacus, was a prophetess”: Gender and Utopia in Three Spartacus Novels

, 1969
R. B. Paul
openalex   +2 more sources