Results 261 to 270 of about 6,703,893 (341)

Social Connectedness Factors that Facilitate Use of Healthcare Services: Comparison of Transgender and Gender Nonconforming and Cisgender Adolescents

, 2019
Lindsay A. Taliaferro, Brittany M. Harder, Nik M. Lampe, Shannon K. Carter, G. Nic Rider, Marla E. Eisenberg   +5 more
openalex   +2 more sources

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Gender gaps in healthy life expectancy as indicators of inequality for disability and chronic disease: cross-sectional evidence from 24 countries, years 2014-2019. [PDF]

BMJ Open
Di Lego V, Nepomuceno MR, Turra CM.
europepmc   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Why orthopaedics and trauma surgery loses part of its future workforce - a cross-sectional study of gender differences in medical students' specialty choice. [PDF]

BMC Med Educ
Ketzer C, Sinz A, Bielesch G, Müller C, Achtnich A, Biberthaler P, Hanschen M, Bohe O.   +7 more
europepmc   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

From Gender Threat to Farsightedness: How Women's Perceived Intergroup Threat Shapes Their Long-Term Orientation. [PDF]

Behav Sci (Basel)
Shi Y, Zhao Y, Ma X, Chen S.
europepmc   +1 more source

Gender: The Basics

, 2013
openaire   +2 more sources

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Utilizing telemedicine to enhance access to Gender Expression Care for transgender and gender diverse individuals. [PDF]

Sci Rep
Chan SW, Prata M, Firtch G, Avins A, Pressman A.   +4 more
europepmc   +1 more source