Results 261 to 270 of about 6,987,836 (365)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu   +11 more
wiley   +1 more source

Adrenal Biomarkers of Stress in Transgender and Gender-Diverse Adolescents. [PDF]

open access: yesDev Psychobiol
Coslovich S   +9 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

Bullying, State Policy, and Mental Health Symptoms in Gender-Diverse Youths.

open access: yesJAMA Netw Open
Hughes DE   +14 more
europepmc   +1 more source

From preoperative to postoperative: gender differences in elective ventral hernia repair. [PDF]

open access: yesHernia
Head W   +5 more
europepmc   +1 more source

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