Results 121 to 130 of about 766,696 (285)

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Gender-based violence in higher education institutions in Ecuador: a systematic literature review

Frontiers in Education
Gender-based violence in Ecuador’s higher education institutions (HEIs) is a structural and widespread problem, rooted in patriarchal sociocultural norms.
Kenia Laz-Figueroa, Fabricio Guevara-Viejó, Juan Diego Valenzuela-Cobos, Brizeida Raquel Hernández-Sánchez, José Carlos Sánchez-García   +4 more
doaj   +1 more source

Насильство у телесеріалах та формування гендерної ідентичності в молодіжній аудиторії (Violence in television series, and the formation of gender identity in the youth audience) [PDF]

, 2016
У статті з’ясовано, як закріплено і передано комунікативний образ гендерного насильства в телесеріалах, і навпаки, як і чому суспільство, культура дозволяють зберігати насильство в самому дискурсі телесеріалу.
Гулевський, C. (Gulevsky S.)
core  

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Implausible incarceration data need to be addressed – Authors' reply

The Lancet Global Health, 2013
Rachel Jewkes, Emma Fulu, Xian Warner, James Lang   +3 more
doaj   +1 more source

Gender-Based Violence in the Context of Mothering: A Critical Canadian Health Perspective

Societies
Violence against women is a predominant, human rights violation, globally. Understood as any act of gender-based violence resulting in physical, sexual, or psychological harm or suffering to women, approximately 35% of women experience violence across ...
Tara Mantler, Kimberley Teresa Jackson
doaj   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

PARALLEL GENDER REPRESENTATION IN ISSUES OF CONFLICT RELATED VIOLENCE: A PRE-REQUISITE FOR PEACE AND DEVELOPMENT IN POST-CONFLICT SOCIETIES [PDF]

, 2016
Peace building in the aftermath of war related violence is a prerequisite for the development of post conflict societies. More often than not, women are assumed to be the only victims in cases of gender based violence and rarely is consideration given to
Awogu-Maduagwu, Edith Abisola, Ovia, Ebikaboere, Uba, Emmanuel   +2 more
core  

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source