Results 111 to 120 of about 272,480 (311)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Educational intervention on sexual violence to empower university students in developing healthy affective-sexual relationships

Heliyon
Introduction: Sexual violence (SV) is frequent in universities, and a link has been demonstrated between SV and toxic substance use by university students in leisure settings. In Spain there is little scientific evidence in this regard, and SV prevention
Alba Berenguer-Simon, David Ballester-Ferrando, Carolina Rascón-Hernán, Zaira Reyes-Amargant, Dolors Rodríguez-Martín, Concepció Fuentes-Pumarola   +5 more
doaj   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Student and faculty perspectives of gender inclusive and affirming practices in undergraduate nursing education

Background: Transgender and gender diverse people have unique healthcare needs, which can be addressed through the provision of gender affirming care. Nurses, the largest healthcare workforce, can help meet this need.
Crawford, Jess
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Developing a holistic AI literacy assessment matrix – Bridging generic, domain-specific, and ethical competencies

Computers and Education Open
Motivated by a holistic understanding of AI literacy, this work presents an interdisciplinary effort to make AI literacy measurable in a comprehensive way, considering generic and domain-specific AI literacy as well as AI ethics.
Nils Knoth, Marie Decker, Matthias Carl Laupichler, Marc Pinski, Nils Buchholtz, Katharina Bata, Ben Schultz   +6 more
doaj   +1 more source

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Multicenter cross-sectional study on sexual violence among university students: victims, perpetrators, and alcohol use

Frontiers in Public Health
ObjectiveThis study aims to estimate the prevalence of sexual violence among university students (identification of sexual violence behaviors, self-recognition as victims and perpetrators) and its relationship with alcohol consumption and other ...
Alba Berenguer-Simon, Alba Berenguer-Simon, David Ballester-Ferrando, Zaira Reyes-Amargant, Zaira Reyes-Amargant, Paola Galbany-Estragués, Paola Galbany-Estragués, Elena Maestre-González, Elena Maestre-González, Eva María Garrido-Aguilar, Maria Dolors Burjalés-Marti, Rebeca Gomez-Ibañez, Eva Serrat-Graboleda, Dolors Rodríguez-Martín, Dolors Rodríguez-Martín, Concepció Fuentes-Pumarola   +15 more
doaj   +1 more source

The Association Among Gender Diversity, Board Characteristics and Firms Performance

The current research explores the association among gender diversity, board characteristics, and company performance in Palestinian industrial firms listed on the Palestine Stock Exchange (PSE).
Abughaush, Suhaila, Masa’deh, Ra’ed, Almanadheh, Yazan, Samara, Husni   +3 more
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source