Results 181 to 190 of about 2,619,234 (375)

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

open access: yesAdvanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang   +12 more
wiley   +1 more source

Gender, Distribution, and Balance of Payments (revised 10/08) [PDF]

open access: yes
An unresolved debate in the development literature concerns the impact of gender inequality on economic growth. Previous studies have found that the effect depends on the time frame (short or long run) and the measure of inequality.
Stephanie Seguino
core  

Gender and the Sharing Economy [PDF]

open access: yes, 2016
While the sharing economy has been celebrated as a flexible alternative to traditional employment for those with family responsibilities, especially women, it presents challenges for gender equality.
Schoenbaum, Naomi
core   +2 more sources

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Return on Equality: Investment Opportunities that Help Close the Global Gender Gap [PDF]

open access: yes, 2017
There is significant opportunity for individual investors, asset managers and companies to move closer to achieving the goal of gender equality and make direct social, market and global economic impacts, according to a compelling report launched today by

core  

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

open access: yesAdvanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu   +17 more
wiley   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

open access: yesAdvanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang   +51 more
wiley   +1 more source

How language can be used to promote gender equality in geoscience [PDF]

open access: gold, 2023
Olga Nardini   +3 more
openalex   +1 more source

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