Results 191 to 200 of about 761,611 (384)

EIF4A3‐Mediated Biogenesis of CircFADS1 Promotes the Progression of Hepatocellular Carcinoma via Wnt/β‐Catenin Pathway

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
In this study, a novel circRNA, circFADS1 is identified, which is expressed at higher levels in HCC. circFADS1 is associated with poor prognosis in HCC patients and promotes HCC cell proliferation while inhibiting apoptosis. Mechanistically, circFADS1 exerts its biological function through the EIF4A3/GSK3β/β‐catenin axis and is closely associated with ...
Lei Tang   +7 more
wiley   +1 more source

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen   +16 more
wiley   +1 more source

Does gender-equality concern with non-communicable diseases in India? [PDF]

open access: yesLancet Reg Health Southeast Asia, 2023
Gupta H, Nigam N.
europepmc   +1 more source

Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Osteoarthritis is a common joint disease globally, bringing heavy social and economic burdens. Ferroptosis in OA, due to inflammation or iron overload, is a key factor. In this study, Ce@D&P nanoparticles (NPs) are developed to perform multitarget regulation of ferroptosis.
Dong Wang   +10 more
wiley   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy