Results 181 to 190 of about 2,541,476 (263)

Le genre au tribunal : l’hermaphrodisme devant la France d’Ancien Régime

Glad!, 2018
Mathieu Laflamme
doaj   +1 more source

Alzheimer's disease and related dementias among transfeminine adults: A cohort study. [PDF]

Alzheimers Dement
Cicero EC, Flatt JD, Kaabi O, Tangpricha V, Getahun D, McCracken C, Lash TL, Silverberg MJ, Vupputuri S, Perkins M, Barnes LL, Goodman M.   +11 more
europepmc   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Pyloric Metrics and Distensibility Plateau by Functional Luminal Imaging Probe in Pediatric Patients: A Pilot Study. [PDF]

Neurogastroenterol Motil
Osgood PT, Hoffmann NV, Wechsler JB, Pantazopoulos R, Fortunato JE.   +4 more
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Intersecting Sex Work and Substance Use Risk Among Sexual and Gender Minoritized Individuals Recruited Online in San Francisco, California: Survey Results.

JMIR Public Health Surveill
Arayasirikul S, Maycott J, Olivares A.
europepmc   +1 more source

Nuances of Gender Identity for a Transgender Patient Receiving Inpatient Treatment for Paranoid Schizophrenia: A Case Study. [PDF]

Case Rep Psychiatry
Suri RK, Heslin KP, Sperry S, Leontieva L.   +3 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Potential Impact of Childhood Abuse on Quality of Life During Mood-Stabilising Treatment in Individuals Living With Bipolar Disorder. [PDF]

Bipolar Disord
Wrobel AL, Dean OM, Lotfaliany M, Berk M, Sylvia LG, Thase ME, Deckersbach T, Tohen M, McInnis MG, Kocsis JH, Shelton RC, McElroy SL, Turner A, Nierenberg AA.   +13 more
europepmc   +1 more source