Navigating Body Perception, Affectivity, Intimacy, Gender Identity, and Sexuality: An Exploratory Qualitative Study in Young Adults with SMI, IDs, and ASD in a Community Setting. [PDF]
Belluzzo M+5 more
europepmc +1 more source
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge+7 more
wiley +1 more source
Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu+14 more
wiley +1 more source
The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu+5 more
wiley +1 more source
Capturing sexual orientation and gender identity information in electronic medical records to inform the person-centred care of sexual and gender minority people. [PDF]
Schmidt S+6 more
europepmc +1 more source
Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids
This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu+9 more
wiley +1 more source
Preliminary development of a brief parent-report gender identity alignment/distress screener for children. [PDF]
Diemer MA, Hillier A, Marcus SC.
europepmc +1 more source
Single‐Droplet Dual‐Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening
Circular RNAs are crucial in tumorigenesis. This study identifies circCK1γ3 and circWDR37 as dual plasma biomarkers for colorectal cancer (CRC) screening. It is developed Casµchip, a droplet microfluidic chip using Cas13a/b technology to quantify these biomarkers.
Jingsong Xu+11 more
wiley +1 more source