Results 51 to 60 of about 658,707 (299)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Gender Issues

, 2011
Gender is an important social category that affects adolescents' lives in multiple ways. Gender identities and gender schemas shape the kinds of ideas and behaviors that adolescents may consider appropriate for themselves and others. Stereotyped beliefs may lead to sexism, including prejudiced attitudes and discriminatory behaviors.
Daniels, EA, Leaper, C
openaire   +4 more sources

Developing an index for measuring gender lens investing in organizations: the GLIMETRICS framework

Frontiers in Psychology
IntroductionThe objective of this article is to develop and validate a metric for assessing gender lens investing (GLI) practices within organizations. The validation of these measurement items constitutes a methodological innovation, responding to calls
Maite Palomo-Vadillo, Ana-Lucia Ortega-Larrea, María-Julia Bordonado-Bermejo, Carmen De-Pablos-Heredero   +3 more
doaj   +1 more source

The provision of childcare services : a comparative review of 30 European countries [PDF]

, 2009
In recent decades, childcare services have become a matter of serious public concern. Affordable and good-quality childcare services may improve the reconciliation of work and family life and thus foster labour market participation and gender equality.
Camilleri-Cassar, Frances, Remery, Chantal, European Commission’s Expert Group on Gender and Employment Issues (EGGE), Plantenga, Janneke   +3 more
core  

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Brazil Gender Review : Issues and Recommendations

, 2002
The report, which documents findings of a review on gender issues in Brazil, during 1999, and updated in 2001, is responsive to the recognition of gender as an important issue in increasing socioeconomic
World Bank
core   +1 more source

Reconsidering feminisms and the work of Norbert Elias for understanding gender, sport and sport-related activities [PDF]

, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2008 North West Counties Physical Education Association and SAGE Publications.This paper reconsiders the relationships between feminist ...
Mansfield, L, Mansfield, L.
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source