Results 41 to 50 of about 1,573,573 (279)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Designing Women: Essentializing Femininity in AI Linguistics [PDF]
, 2019 Since the eighties, feminists have considered technology a force capable of subverting sexism because of technology’s ability to produce unbiased logic.
Vega, Ellianie S.
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Aware and unaware- stereotypes and gender scripts in family narratives in the process of education [PDF]
Studia z Teorii WychowaniaThe aim of the article is to discuss the issues of shaping gender roles in children of early school age, taking into account the importance of stereotypes and gender scripts in this process.First of all, the basic concepts of roles, stereotypes and ...
Magda Karkowska
doaj +1 more source
Gender roles and women’s labor market outcomes
China Economic Quarterly International, 2021 Using the China General Social Survey data, we tried to examine the impact of gender roles on women’s labor market outcomes. We find that traditional gender roles emphasizing women’s responsibility for housework are negatively related to the employment ...
Zhang Chuanchuan, Wang Jingwen
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Gender roles and technological progress [PDF]
, 2007 Until the early decades of the 20th century, women spent more than 60% of their prime-age years either pregnant or nursing. Since then, the introduction of infant formula reduced women's comparative advantage in infant care, by providing an effective ...
Albanesi, Stefania, Olivetti, Claudia
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Beauty and the Barrister: Gender Roles, Madness, and the Basis for Identity in Lady Audley\u27s Secret [PDF]
, 2014 This thesis examines the concept of identity in the novel Lady Audley’s Secret by Mary Elizabeth Braddon. In the mid to late Victorian period, self-definition was strongly tied to gender roles.
Hayes, Corey
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Daughter preference in Japan: A reflection on gender role attitudes?
Demographic Research, 2013 BACKGROUND Unlike other East Asian nations where preference for sons over daughters still prevails, gender preference for children in Japan has progressively shifted from son preference to a noticeable daughter preference over the past few decades.
Kana Fuse
doaj