Results 91 to 100 of about 95,154 (291)

The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1

Advanced Science, EarlyView.
The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong, Zhenling Wang, Yong Wang, Yang Chen, Hongqiang Zhang, Yunfei Lu, Lei Xu, Hengyang Shen, Changzhi Huang, Min Zhao, Wenjie Li, Shuai Wang, Yu Shao, Zan Fu   +13 more
wiley   +1 more source

‘We do not like talking about our problems’: socialization and idealized masculinity as drivers of help-seeking avoidance among college men in South Africa

BMC Public Health
Background This article explores how identities and contexts influence help-seeking avoidance behaviour among college men. Methods This exploratory qualitative study purposively selected 88 male students (aged 18–30) from some universities and Technical ...
Yandisa Sikweyiya, Pinky Mahlangu, Rachel Jewkes, Carrie Brooke-Sumner, Andrew Gibbs, Elizabeth Dartnall, Managa Pillay, Mercilene Machisa   +7 more
doaj   +1 more source

Human trafficking and violence: Findings from the largest global dataset of trafficking survivors

Journal of Migration and Health, 2021
Background: Human trafficking is a recognized human rights violation, and a public health and global development issue. Violence is often a hallmark of human trafficking. This study aims to describe documented cases of violence amongst persons identified
Heidi Stöckl, Camilla Fabbri, Harry Cook, Claire Galez-Davis, Naomi Grant, Yuki Lo, Ligia Kiss, Cathy Zimmerman   +7 more
doaj  

Dismantling Gender Blindness in Online Discussion of a Crime/Gender Dichotomy [PDF]

Contemporary feminists utilize social media for activism, while backlashes come along. The gender-related discourses are often diminished when addressing public events regarding sexism and gender inequality on social media platforms. The dichotomized debate around the Tangshan beating incident in China epitomized how criminal interpretations of gender ...
arxiv   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Bias Gender Sebagai Prediktor Kekerasan Dalam Rumah Tangga

Jurnal Psikologi, 2013
This article presents a meta‐analysis of the survey literature that has examined gender bias as predictors of domestic violence. A meta – analysis of 62 studies from 35 articles, 33 researchers and 53423 subjects evaluated the correlation ...
Anugriaty Indah Asmarany
doaj   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Gender and content bias in Large Language Models: a case study on Google Gemini 2.0 Flash Experimental [PDF]

Frontiers in Artificial Intelligence (2025) 8:1558696
This study evaluates the biases in Gemini 2.0 Flash Experimental, a state-of-the-art large language model (LLM) developed by Google, focusing on content moderation and gender disparities. By comparing its performance to ChatGPT-4o, examined in a previous work of the author, the analysis highlights some differences in ethical moderation practices ...
arxiv   +1 more source

What matters for agricultural trade? Assessing the role of trade deal provisions using machine learning

Applied Economic Perspectives and Policy, EarlyView.
Abstract This paper employs machine learning to determine which preferential trade agreement (PTA) provisions are relevant to agricultural trade patterns and the factors that may influence their adoption. Utilizing the three‐way gravity model, we apply plug‐in Lasso regularized regression to pinpoint predictive PTA provisions for agricultural trade ...
Stepan Gordeev, Jeremy Jelliffe, Dongin Kim, Sandro Steinbach   +3 more
wiley   +1 more source

Fight like a Woman: Domestic Violence and Female Judges in Brazil [PDF]

arXiv
We investigate the impact of judges' gender on the outcome of domestic violence cases. Using data from S\~ao Paulo, Brazil, between 2010 and 2019, we compare conviction rates by judge's gender and find that a domestic violence case assigned to a female judge is 31\% (10 p.p.) more likely to result in conviction than a case assigned to a male judge with
arxiv