Results 91 to 100 of about 2,841,595 (307)

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

‘We do not like talking about our problems’: socialization and idealized masculinity as drivers of help-seeking avoidance among college men in South Africa

BMC Public Health
Background This article explores how identities and contexts influence help-seeking avoidance behaviour among college men. Methods This exploratory qualitative study purposively selected 88 male students (aged 18–30) from some universities and Technical ...
Yandisa Sikweyiya, Pinky Mahlangu, Rachel Jewkes, Carrie Brooke-Sumner, Andrew Gibbs, Elizabeth Dartnall, Managa Pillay, Mercilene Machisa   +7 more
doaj   +1 more source

Alcohol other drugs and family violence

Our two page briefs are designed to provide a snapshot of key terms and definitions, legislation, services and research towards preventing family violence. The briefs are provided in PDF format. To access this information in additional accessible formats,

core   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

New Directions for Preventing Dating Violence in Adolescence: The Study of Gender Models

Frontiers in Psychology, 2018
Dating violence is a huge transcultural and alarming phenomenon, directly linked with endless discrimination against women. The latest research on dating violence in adolescence shows how dating violence is persistent and common in the adolescent period ...
Chiara Santoro, Belén Martínez-Ferrer, Carmen Monreal Gimeno, Gonzalo Musitu   +3 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Much to be done: towards an effective transitional justice model for dealing with conflict-related crimes of sexual and gender-based violence [PDF]

, 2014
Many countries in Africa have experienced conflicts characterized by gross human rights violations, including widespread and systematic sexual and gender-based violence.
Mazimhaka, Anne P Inturire
core   +1 more source

Reproductive healthcare use before and after infertility diagnosis: a population-based study in South Korea

BMJ Open
Objectives This study examines heterogeneity in women’s use of reproductive healthcare services before and after receiving an infertility diagnosis and its association with pregnancy identified without recorded loss within one year following the first ...
Juhyeon Moon, Boyoung Jeon
doaj   +1 more source

Gender-related violence: its scope and relevance

, 1993
Violence against women is a complex, worldwide, issue of human rights. It has so far been scarcely documented, and this article provides a crucial overview of the key issues.
El-Bushra, Judy, Eugenia Piza-Lopez
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source