Results 41 to 50 of about 2,841,595 (307)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Engaging men to transform inequitable gender attitudes and prevent intimate partner violence: a cluster randomised controlled trial in North and South Kivu, Democratic Republic of Congo

BMJ Global Health, 2020
Introduction The study objective was to understand the effectiveness of Engaging Men through Accountable Practice (EMAP), a group-based discussion series which sought to transform gender relations in communities, on intimate partner violence (IPV ...
Julia Vaillant, Estelle Koussoubé, Danielle Roth, Rachael Pierotti, Mazeda Hossain, Kathryn L Falb   +5 more
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Mental health, violence and psychological coercion among female and male trafficking survivors in the greater Mekong sub-region: a cross-sectional study

BMC Psychology, 2018
Background Human trafficking is a pervasive global crime with important public health implications that entail fundamental human rights violations in the form of severe exploitation, violence and coercion.
Lisbeth Iglesias-Rios, Siobán D. Harlow, Sarah A. Burgard, Ligia Kiss, Cathy Zimmerman   +4 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

The ethics of knowledge sharing: a feminist examination of intellectual property rights and open-source materials in gender transformative methodologies

Frontiers in Research Metrics and Analytics
Debates on intellectual property rights and open source frequently stem from the business sector and higher education, where goals are typically oriented toward profit, academic status, credit, and/or reputation.
Leah Goldmann, Alice Welbourn, Diane Gillespie, Nastnet Ghebrebhran, Lufuno Barro, Sara Siebert, Hawa Kagoya, Lori Michau, Anjalee Kohli, Tina Musuya, Sonia Rebecca Kusiima   +10 more
doaj   +1 more source

The sociological significance of domestic violence: Tensions, paradoxes and implications [PDF]

, 2013
Sociology and sociological theory has been effective in analyzing societal and institutional conflict and violence, but less so the specifics of interpersonal violence. This article examines the sociological significance of domestic violence.
Hearn, Jeff,, Jeff Hearn, Hearn, Jeff
core   +1 more source

UniSAFE Survey – Gender-based violence and institutional responses

, 2022
The UniSAFE survey collected data on experiences of gender-based violence, including sexual harassment, among students and employees in 46 higher education institutions and research institutions in 15 countries in the period 17.01.-01.05.2022 (n= 42,186).
Baumann, H., Baumann, Horst, GESIS Leibniz Institute for the Social Sciences, Lomazzi, Vera, GESIS Leibniz Institute for the Social Sciences, Freund, F., Lomazzi, V., Schredl, Claudia, GESIS Leibniz Institute for the Social Sciences, Tanwar, J., Schredl, C., Lipinsky, A., Lipinsky, Anke, GESIS Leibniz Institute for the Social Sciences, Tanwar, Jagriti, Oxford Brookes University, Humbert, A. L., Humbert, Anne Laure, Oxford Brookes University, Bondestam, Fredrik, University of Gothenburg, Freund, Frederike, GESIS Leibniz Institute for the Social Sciences, Bondestam, F.   +15 more
core   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source