Results 161 to 170 of about 1,574,651 (334)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.

, 2000
Robert Walter, David Gottlieb, George O'connor   +2 more
openalex   +1 more source

Airborne Occupational Exposure and ABO Phenotype: An Example of Gene-Environment Interaction in Ischaemic Heart Disease? [PDF]

, 2002
K. W. Lee, G. Y. H. Lip
openalex   +1 more source

Lessons Learned From Past Gene-Environment Interaction Successes

American Journal of Epidemiology, 2017
B. Ritz, N. Chatterjee, M. García-Closas, W. Gauderman, B. Pierce, P. Kraft, C. Tanner, Leah E. Mechanic, K. McAllister   +8 more
semanticscholar   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses. [PDF]

Br J Cancer, 2023
Dimou N, Kim AE, Flanagan O, Murphy N, Diez-Obrero V, Shcherbina A, Aglago EK, Bouras E, Campbell PT, Casey G, Gallinger S, Gruber SB, Jenkins MA, Lin Y, Moreno V, Ruiz-Narvaez E, Stern MC, Tian Y, Tsilidis KK, Arndt V, Barry EL, Baurley JW, Berndt SI, Bézieau S, Bien SA, Bishop DT, Brenner H, Budiarto A, Carreras-Torres R, Cenggoro TW, Chan AT, Chang-Claude J, Chanock SJ, Chen X, Conti DV, Dampier CH, Devall M, Drew DA, Figueiredo JC, Giles GG, Gsur A, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Jordahl K, Kawaguchi E, Keku TO, Larsson SC, Le Marchand L, Lewinger JP, Li L, Mahesworo B, Morrison J, Newcomb PA, Newton CC, Obon-Santacana M, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Peoples AR, Pharoah PDP, Platz EA, Potter JD, Rennert G, Scacheri PC, Schoen RE, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Ulrich CM, Um CY, van Duijnhoven FJB, Visvanathan K, Vodicka P, Vodickova L, White E, Wolk A, Woods MO, Qu C, Kundaje A, Hsu L, Gauderman WJ, Gunter MJ, Peters U.   +87 more
europepmc   +1 more source

The Role of Gene-Environment Interactions in the Development of Respiratory Disorders [PDF]

, 2002
Dharam P. Agarwal
openalex   +1 more source

Genome‐wide gene‐environment interaction in depression: A systematic evaluation of candidate genes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018
S. Van der Auwera, W. Peyrot, Y. Milaneschi, Johannes Hertel, B. Baune, G. Breen, Enda M. Byrne, E. Dunn, H. Fisher, G. Homuth, D. Levinson, C. Lewis, Natalie T. Mills, N. Mullins, M. Nauck, G. Pistis, M. Preisig, M. Rietschel, S. Ripke, P. Sullivan, A. Teumer, H. Völzke, D. Boomsma, N. Wray, B. Penninx, H. Grabe   +25 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Roudtable Discussion: Methodologic issues in studying gene-environment interactions in cancer research

, 2000

openalex   +1 more source