Results 161 to 170 of about 15,130,803 (334)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Gene-environment interaction and personality/behaviour

Annals of General Psychiatry, 2006
Göktürk Camilla, Wargelius Hanna, Olerud Ingrid, Sjöberg Rickard, Nilsson Kent, Lindström Leif, Hallman Jarmila, Oreland Lars, Öhrvik John, Leppert Jerzy   +9 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Gene-environment interaction in problematic substance use behaviours: Risk for tobacco, cannabis and alcohol use due to the joint action of the DRD4 EXON III 7-repeat-derivatives and insecure attachment style

, 2009
Gene-environment interaction in problematic substance use behaviours: Risk for tobacco, cannabis and alcohol use due to the joint action of the DRD4 EXON III 7-repeat-derivatives and insecure attachment ...
G Patton (7746530), Craig Olsson (13064958), E Moore (9663458), G Byrnes (13296708), J Ellis (7807520)   +4 more
core  

Effect of gene-environment interaction on laryngeal cancer risk.

, 2014
Ref: used as reference values. ORC: Crude Odds Ratio; ORa: Odds Ratio adjusted by logic regression based on age, gender, smoking, and drinking status; 95% CI: 95% confidence interval.Effect of gene-environment interaction on laryngeal cancer risk.
Liyan Ni (129626), Shiyu Liao (589987), Faming Lin (642086), Jianhua Jin (537722), Qiyu Bao (8800)   +4 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Supplementary Figure 2 from A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social Isolation

, 2009
Supplementary Figure 2 from A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social ...
Masha Kocherginsky (846813), Deng Pan (47215), Suzanne D. Conzen (14906076), Thomas Krausz (14885687), Bertha Delgado (14975383), Jane He (15091890), J. Bradley Williams (15091884), Maria Tretiakova (17180), Martha K. McClintock (12084941), Diana Pang (15091887)   +9 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

A Multi-Level Organization of Semantic Primitives that Enables an Autonomous Design Agent to Learn Model of Interaction with the Environment

, 2007
: The intelligent systems that design in an environment require models of environment. Autonomous learning agents, that start with no models of environment, need to generate models of environment.
Learn Model, Me Nt, Interaction Environment   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source